Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Name: 2,3-Dichlorobenzaldehyde.
Das, Tushar;Ranjan, Amit;Sieron, Leslaw;Maniukiewicz, Waldemar;Das, Subrata research published 《 Direct Synthesis, Characterization and Theoretical Studies of N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide Derivatives》, the research content is summarized as follows. A highly atom profitable nucleophilic addition reaction of aromatic aldehydes and heterocyclic amines for the generation of amides I [R = Ph, 2-furanyl, benzylidene, etc.] having an excellent yield and high reproducibility were reported. The main force responsible for the forward reaction was the presence of the nitroso group at the C-5 position on uracil scaffold, which resulted in the formation of formidable range products. The conclusive mechanism was based on the dehydrogenation reaction of the carbinolamine product formed during the nucleophilic addition reaction of the aromatic aldehyde with the free heterocyclic amino group to yield the corresponding amides. The synthesized compounds I were predicated for biol. properties and proved it to be an ideal G protein-coupled receptor kinase2 (GRK2) inhibitor. Out of all, the compound I [R = 2-methoxyphenyl] showed the most preeminent properties when compared to Paroxetine, studied using mol. docking. At the same time, computed ADME anal. proved them as an ideal drug candidate. These findings not only prophesied new methods for the synthesis of bioactive-amides using a cross-coupling strategy but also demonstrated their novel applications as a human GRK2 inhibitor.
6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Name: 2,3-Dichlorobenzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics