The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. SDS of cas: 349-88-2.
Das, Sumit;Roy, Shantonu;Bhowmik, Arup;Sarkar, Writhabrata;Mondal, Imtiaj;Mishra, Aniket;Saha, Shubhra Jyoti;Karmakar, Sudip;Deb, Indubhusan research published 《 A radical-radical cross-coupling reaction of xanthene with sulfonyl hydrazides: facile access to xanthen-9-sulfone derivatives》, the research content is summarized as follows. A straightforward strategy for direct incorporation of sulfonyl units into a xanthene moiety for accessing xanthen-9-sulfone derivatives I (R = n-Bu, Cl, Ph, etc.; R1 = H, Me, F, Br, etc.; R2 = H, OMe; R3 = H; R2R3 = -CH=CH-CH=CH-) in good to excellent yields has been established via metal-free radical-radical cross-coupling reaction of xanthenes II and sulfonyl hydrazides RS(O)2NHNH2. Using easily accessible starting materials, this methodol. proceeds efficiently with a high degree of functional group compatibility and with a wide scope of both xanthenes II and sulfonyl hydrazides under operationally simple reaction conditions. Mechanistic investigations revealed that sulfonyl radicals could be generated from sulfonyl hydrazides in the presence of TBHP under an oxygen atm.
SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics