Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride.
Col, Omer Faruk;Bozbey, Irem;Turkmenoglu, Burcin;Uysal, Mehtap research published 《 3(2H)-Pyridazinone derivatives: Synthesis, in-silico studies, structure-activity relationship and in-vitro evaluation for acetylcholinesterase enzyme inhibition》, the research content is summarized as follows. New ten compounds bearing pyridazinone ring I [R = Me, MeO, Cl; R1 = H, F3C, F, Cl] were designed and synthesized as acetylcholinesterase inhibitors. The new derivatives I were acquired via the reaction of propionohydrazides with substituted/nonsubstituted sulfonylchlorides. The structures of the synthesized compounds I were explained using FT-IR, 1H-NMR, 13C-NMR, elemental anal. and HRMS spectra. The inhibition profiles of the synthesized compounds I on AChE were researched by comparing their IC50 and KI values. According to the activity studies, all the compounds I showed significant inhibitory activity against AChE relative to the reference compound Tacrine. The compound I [R = Me, R1 = F] showed the best acetylcholinesterase inhibitory effect with a KI value of 11.61 ± 0.77 nM. For all compounds, I the parameters of the interaction points on the receptor side were determined on the ligand basis with the 4D-QSAR model. The synthesized pyridazinone derivatives, I were screened for their acetylcholinesterase inhibitory potential, and the results determined that among the series, compounds I [R = Me, R1 = F, Cl; R = MeO, R1 = F3C] showed the best inhibition, resp. For anti-Alzheimer activities, compounds I [R = Me, R1 = F, Cl; R = MeO, R1 = F3C] were performed in-silico studies to understand the binding site, binding energy properties in mol. docking.
Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics