Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. SDS of cas: 6334-18-5.
Buduma, Komuraiah;Kumar A, Niranjana;Srinivas K. V. N., Satya;Kumar J, Kotesh;Chinde, Srinivas;Domatti, Anand Kumar;Kumar, Yogesh;Grover, Paramjit;Tiwari, Ashok;Khan, Feroz research published 《 Synthesis and bioactivity evaluation of eugenol hybrids obtained by Mannich and 1,3-dipolar cycloaddition reactions》, the research content is summarized as follows. Design, synthesis, and bioactivity evaluation of novel Mannich bases I [X = Et2N, (H2NCH2)2N, 1-piperazinyl, 4-morpholinyl, etc.] and triazole-chalcone derivatives II (R = Ph, 4-FC6H4, 2,3-Cl2C6H3, 1-naphthyl, 2-furyl, etc.) of eugenol are reported. Among all the derivatives tested for antiproliferative activity, Mannich derivative I [X = (H2NCH2)2N] (32.92μM), and triazole II (R = 4-MeOC6H4) (33.05μM) significantly inhibited HepG2 cell lines when compared to the standard doxorubicin (37.29μM). Mannich bases I (X = Et2N) (17.75μM), I [X = (H2NCH2)2N] (17.02μM) and I [X = (ClCH2)2N] (20.12μM) showed moderate to better inhibition towards MCF-7 cell lines. The synthesized analogs were also tested for antidiabetic and antiobesity potentials. The compounds I [X = 4-(2-hydroxy-3-methoxy-5-allylbenzyl)piperazinyl] (55.50%), I [X = (ClCH2)2N] (54.34%), II (R = 2-O2NC6H4) (55.5%), and I (X = Et2N) (55.5%) have shown moderate inhibitory potentials toward intestinal α-glucosidase enzyme when compared to the standard Acarbose (72.86%). Likewise, compounds II (R = 4-MeOC6H4) (82.95%), II (R = 4-ClC6H4) (76.19%), II (R = 2-O2NC6H4) (74.81%), II (R = 2,3-Cl2C6H3) (74.81%), and I (X = 4-methyl-1-piperazinyl) (72.50%) have shown significant to moderate inhibitory potentials toward Pancreatic lipase enzyme when compared to the standard orlistat (91.10%). ROS induces life-threatening diseases like diabetes, cancer, etc., and antioxidants play a major role in controlling their production Compounds I [X = (ClCH2)2N] (99.81%), I (X = 4-carboxy-1-piperidinyl) (99.80%), I [X = (HOCH2)2N] (99.26%), I (X = 4-methyl-1-piperazinyl) (98.79%), and I [X = 4-(2-hydroxy-3-methoxy-5-allylbenzyl)piperazinyl] (98.42%) have shown significant antioxidant profiles in ABTS assay when compared to the standard Trolox (99.07%). Further, in silico mol. docking and pharmacokinetic screening of the eugenol derivatives complemented the in vitro results indicating the drug likeness of the obtained active compounds
SDS of cas: 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics