Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Synthetic Route of 104-86-9.
Borkar, Maheshkumar R.;Martis, Elvis A. F.;Nandan, Santosh;Patil, Rajendra H.;Shelar, Amruta;Iyer, Krishna R.;Raikuvar, Kavita;Desle, Deepali;Coutinho, Evans C. research published 《 Identification of potential antileishmanial 1,3-disubstituted-4-hydroxy-6-methylpyridin-2(1H)-ones, in vitro metabolic stability, cytotoxicity and molecular modeling studies》, the research content is summarized as follows. The synthesis and in vitro evaluation of 1,3-disubstituted-4-hydroxy-6-methylpyridin-2(1H)-one derivatives I (R1 = Pr, Bn, cyclopropyl, etc.; R2 = H, Me, Br, OMe) against Leishmania donovani is reported. Amongst the compound library synthesized, mols. few compounds demonstrated substantial dose-dependent killing of the promastigotes. Their IC50 values range from 55.0 to 77.0μg/mL, with I (R1 = 4-FC6H4CH2; R2 = H) (IC50 55.75μg/mL) being equipotent with amphotericin B (IC50 50.0μg/mL, used as standard) and this most stable compound is metabolically stable in rat liver microsomes. Furthermore, the mols. are highly specific against leishmania as shown by their weak antibacterial and antifungal activity. In vitro cytotoxicity studies show the compounds lack any cytotoxicity. Furthermore, mol. modeling studies show plausibility of binding to Leishmania donovani topoisomerase 1 (LdTop1). Structure activity relationships reveal bulky substitutions on the pyridone nitrogen are well-tolerated, and such compounds have better binding affinity. Intramol. hydrogen bonds confer some rigidity to the mols., rendering a degree of planarity akin to topotecan. Taken together, the emphasis on the merits of mols. possessing the 1,3-disubstituted-4-hydroxy-6-methylpyridin-2(1H)-one skeleton as potential antileishmanial agents warranting further investigation.
104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., Synthetic Route of 104-86-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics