Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Safety of 4-Fluorobenzene-1-sulfonyl chloride.
Babu, Sakamuri Sarath;Gopinath, Purushothaman research published 《 Photomediated Tandem Sulfonyl Addition-Chemoselective N-Cyclization of o-Alkenyl Aryl Ureas: Direct Assembly of Functionalized Dihydroquinazolinones》, the research content is summarized as follows. Photoredox-mediated tandem addition-chemoselective cyclization of o-alkenyl aryl ureas was reported for the synthesis of sulfonyl and activated alkyl-decorated dihydroquinazolinones I [R = Et, Bn, 4-MeC6H4, etc.; R1 = Et, Bn, CH2-4-MeOC6H4; R2 = CH2CN, SO2Et, SO2-4-MeC6H4, etc.]. By a careful choice of o-alkenyl aryl urea starting materials, chemoselective N-cyclization in the presence of more reactive amidic oxygen was achieved. The scope of the methodol. with a variety of sulfonyl chlorides and activated alkyl halides was discussed. Finally, large-scale synthesis of sulfonyl-substituted dihydroquinazolinone showcased the synthetic utility of the methodol.
Safety of 4-Fluorobenzene-1-sulfonyl chloride, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics