Recommanded Product: 3,3′-Diindolylmethane. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Epigenetic control of pancreatic carcinogenesis and its regulation by natural products. Author is Zubair, Haseeb; Azim, Shafquat; Khan, Mohammad Aslam; Patel, Girijesh Kumar; Ahmad, Aamir; Pai, Sachin; Singh, Seema; Singh, Ajay P..
A review. Pathogenesis of pancreatic cancer (PC) involves both genetic and epigenetic alterations. While genetic aberrations have been the focus of a majority of studies, recent research has highlighted the benefit of therapeutically targeting epigenetic changes because of their reversible nature. Differential promoter DNA methylation of tumor-suppressor genes/oncogenes and chromatin remodeling through histone methylation/acetylation represent some of the more well-characterized epigenetic changes that have been associated with PC onset and progression. A number of key enzymes, such as DNA methyltransferases, histone deacetylases, and enhancer of zeste homolog 2 that play important roles in epigenetic modifications in PC, are targets of anticancer agents obtained from natural products. Prominent among these natural products are 3-3′-diindolylmethane, epigallocatechin-3-gallate, and resveratrol as well as derivatives of curcumin. This chapter provides a comprehensive overview of epigenetic events that are relevant to PC pathogenesis, along with promising emerging data on the regulation of these epigenetic events by natural products.
Different reactions of this compound(3,3′-Diindolylmethane)Recommanded Product: 3,3′-Diindolylmethane require different conditions, so the reaction conditions are very important.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics