COA of Formula: C17H14N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Amelioration of hyperglycemia-induced nephropathy by 3,3′-diindolylmethane in diabetic mice. Author is Choi, Kyeong-Mi; Yoo, Hwan-Soo.
Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. Diabetic nephropathy is a major complication of hyperglycemia. 3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. In mice, STZ induced hyperglycemia, hunger, thirst, and abnormally increased kidney weight and serum creatinine, which is a renal functional parameter. DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. DIM also improved diabetic nephropathy by inhibiting the expression of PKC-a, the marker of albuminuria, and TGF-beta1, an indicator of renal hypertrophy, in diabetic mice. Our findings suggest that DIM may ameliorate hyperglycemia and diabetic nephropathy through the inhibition of PKC-a and TGF-beta1 signaling.
Although many compounds look similar to this compound(1968-05-4)COA of Formula: C17H14N2, numerous studies have shown that this compound(SMILES:C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics