Reference of 1-(tert-Butyl)-1H-pyrrole-2,5-dione. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione, is researched, Molecular C8H11NO2, CAS is 4144-22-3, about Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation. Author is McDaniel, Jonathan R.; Bhattacharyya, Jayanta; Vargo, Kevin B.; Hassouneh, Wafa; Hammer, Daniel A.; Chilkoti, Ashutosh.
We covalently attached 14 different maleimide derivatives of small mols. to a chimeric polypeptide (CP). The CP consisted of a hydrophilic, biodegradable polypeptide and a cysteine-rich Cys(Gly-Gly-Cys)7 segment. An elastin-like polypeptide was selected as the hydrophilic segment of the CP. Attachment of small mols. above a critical threshold of hydrophobicity triggers self-assembly of the CP into soluble nanoparticles. The conjugation-triggered self-assembly can package a hydrophobic drug into soluble nanoparticles.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics