The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Computed Properties of C8H11NO2.Sakai, Norio; Matsumoto, Shun; Ogiwara, Yohei published the article 《Cobalt-catalyzed oxidative annulation of aromatic tertiary amines with electron-deficient maleimides leading to tetrahydroquinoline derivatives》 about this compound( cas:4144-22-3 ) in Tetrahedron Letters. Keywords: tetrahydroquinoline preparation; tertiary amine maleimide oxidative annulation cobalt catalyst. Let’s learn more about this compound (cas:4144-22-3).
A CoCl2-TBHP (t-Bu hydroperoxide) system that efficiently catalyzes the oxidative annulation of aromatic tertiary amines such as N-phenylpiperidine, N,N-dimethyl-p-toluidine, N-methyl-N-ethylaniline, etc. with a typical electron-deficient alkene, N-substituted maleimides I (R = Ph, benzyl, t-Bu, 4-chlorophenyl, 4-methylphenyl), producing the corresponding polycyclic tetrahydroquinoline derivatives, e.g., II, has been described. This oxidizing system could also be applied to the annulation of an electron-rich alkene.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics