The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(tert-Butyl)-1H-pyrrole-2,5-dione( cas:4144-22-3 ) is researched.Synthetic Route of C8H11NO2.Butler, Richard N.; Farrell, Derval M. published the article 《Steric reversal of the endo-selectivity effect in 1,3-dipolar cycloadditions of phthalazinium-2-ylides with N-substituted maleimides: endo- and exo-1,2-(dicarboxy-N-substituted imido)-1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazines》 about this compound( cas:4144-22-3 ) in Journal of Chemical Research, Synopses. Keywords: imidotetrahydropyrrolophthalazine preparation; pyrrolophthalazine imidotetrahydro preparation; cycloaddition phthalaziniumylide maleimide stereochem. Let’s learn more about this compound (cas:4144-22-3).
N-Methyl- and N-arylmaleimides undergo cycloadditions with phthalazinium-2-dicyanomethanide and -2-unsubstituted methanide 1,3-dipoles to give exclusive or predominant endo-cycloadducts, but with N-tert-butylmaleimide this endo effect is reversed to favor the exo-cycloadducts.
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics