Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1968-05-4, is researched, SMILESS is C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4, Molecular C17H14N2Journal, Article, Research Support, Non-U.S. Gov’t, Toxicology and Applied Pharmacology called AKT inhibitor AZD5363 suppresses stemness and promotes anti-cancer activity of 3,3′-diindolylmethane in human breast cancer cells, Author is Zhu, Kaiyuan; Liu, Xu; Liu, Chunxiao; Xu, Yuting; Fu, Yingqiang; Dong, Wei; Yan, Yadong; Wang, Wenjing; Qian, Cheng, the main research direction is diindolylmethane AKT human breast cancer cell anticancer activity; AKT inhibitor; CyTOF; Stemness.Electric Literature of C17H14N2.
The 3,3′-diindolylmethane (DIM) is a dimer compound converted from Indoly-3-carbinol that had been studied as promising chemo-preventive agent against breast cancer. In this study, we observed that proportion of CD133+Nanog+ subpopulation in MCF-7 cells was significantly increased after DIM administration with up-regulated AKT activity by using CyTOF assay. SPADE anal. revealed this stem-like subpopulation exhibited apoptosis-resistance property against DIM treatment. By combining with AKT inhibitor AZD5363, DIM induced CD133 expression could be suppressed. In addition, a combination treatment of MCF-7 and MDA-MB-231 breast cancer cells with DIM and AZD5363 showed synergistic decreases in cell proliferation and induced apoptosis. Furthermore, results from imaging flow cytometry suggested that FoxO3a nuclear localization and PUMA expression could be improved by combination of AZD5363 with DIM. Taken together, the above observations suggested that the combination of AZD5363 with DIM could be developed as potential therapy for breast cancer.
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Chloride – Wikipedia,
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