Recommanded Product: 1968-05-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,3′-Diindolylmethane, is researched, Molecular C17H14N2, CAS is 1968-05-4, about Employing dietary comparators to perform risk assessments for anti-androgens without using animal data.
This study investigated the use of androgen receptor (AR) reporter gene assay data in a non-animal exposure-led risk assessment in which in vitro antiandrogenic activity and exposure data were put into context using a naturally occurring comparator substance with a history of dietary consumption. First, several dietary components were screened to identify which selectively interfered with AR signaling in vitro, using the AR CALUX test. The IC50 values from these dose-response data together with measured or predicted human exposure levels were used to calculate exposure: activity ratios (EARs) for the dietary components and a number of other well-known antiandrogenic substances. Both diindolylmethane (DIM) and resveratrol are specifically acting dietary antiandrogens. The EARs for several antiandrogens were therefore expressed relative to the EAR of DIM, and how this ‘dietary comparator ratio’ (DCR) approach may be used to make safety decisions was assessed using an exposure-led case study for an antiandrogenic botanical ingredient. This highlights a pragmatic approach which allows novel chem. exposures to be put into context against dietary exposures to natural antiandrogenic substances. The DCR approach may have utility for other modes of action where appropriate comparators can be identified.
This literature about this compound(1968-05-4)Recommanded Product: 1968-05-4has given us a lot of inspiration, and I hope that the research on this compound(3,3′-Diindolylmethane) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics