Recently I am researching about CHEMOSELECTIVE HYDROGENATION; PALLADIUM NANOPARTICLES; SELECTIVE HYDROGENATION; RECYCLABLE CATALYST; REDUCTION, Saw an article supported by the Zhejiang Province Public Welfare Technology Research Program [LGG19B040001]; Zhejiang Natural Science FoundationNatural Science Foundation of Zhejiang Province [LY18B020017]; Taizhou Science and Technology Project [1801gy21]. Quality Control of 2-Chloro-6-methylaniline. Published in BMC in LONDON ,Authors: Guo, HC; Zheng, RH; Jiang, HJ; Xu, ZY; Xia, AB. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline
Background The side reactions of dehalogenation or C-N coupling tend to occur when halogenated aromatic amines are prepared by catalytic hydrogenation reduction of halogenated aromatic nitro compounds. In this paper, we prepared the sub-microspherical Fe3O4@PDA-Pd NPs catalyst apply it efficiently in the hydrogenation reduction of halogenated aromatic nitro compounds to prepare the halogenated aromatic amines under atmospheric pressure. The catalyst shows a high selectivity of greater than 96% and can effectively inhibit the occurrence of the side reactions of dehalogenation and C-N coupling. Results The optimum condition of the hydroreduction reaction is when tetrahydrofuran is used as solvent and the reaction happens at 50 degrees C for 5 h. The selectivity of the chlorinated aromatic amine and the fluorinated aromatic amine products exceed 99% and the yield exceeds 90%. Only a small amount of dehalogenated products and C-N coupling by-products were produced in the brominated aromatic compound and the iodinated aromatic compound. Conclusion We developed a promising method for preparing the superparamagnetic and strongly magnetic Fe3O4@PDA core-shell sub-microsphere-supported nano-palladium catalyst for catalyzing the hydrogenation reduction of halogenated aromatic nitro compounds. The halogenated aromatic amines were efficiently and highly selectively prepared under atmospheric pressure, with the side reactions of dehalogenation and C-N coupling effectively inhabited simultaneously.
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Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics