I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system published in 2019. Recommanded Product: 50-84-0, Reprint Addresses Zelaszczyk, D (corresponding author), Jagiellonian Univ, Med Coll, Fac Pharm, Dept Bioorgan Chem,Chair Organ Chem, Krakow, Poland.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid
Searching for CNS active cyclic amines derivatives containing heterocyclic xanthone core we designed and synthesized a set of fourteen novel 2- or 4-methylxanthone substituted by alkyl- or aryl-piperazine moieties. The compounds were evaluated in vivo for their potential antidepressant-like activity (in the forced swim test) and anxiolytic-like activity (four-plate test) and their inhibitory effect against rat 5-HT2 receptor was checked. The pharmacokinetic analysis of active compounds done by a non-compartmental approach have shown a rapid absorption of all studied molecules from intraperitoneal cavity and good penetration the blood-brain barrier after i.p. administration with brain to plasma ratios varied from 2.8 to 31.6. Genotoxicity and biotransformation of active compounds were studied. Compound 19 interactions with major classes of GPCRs, uptake systems and ion channels were tested and results indicated that it binds to 5-HT2A, 5-HT2B receptors and sodium channels.
Recommanded Product: 50-84-0. Welcome to talk about 50-84-0, If you have any questions, you can contact Zelaszczyk, D; Jakubczyk, M; Pytka, K; Rapacz, A; Walczak, M; Janiszewska, P; Panczyk, K; Zmudzki, P; Sloczynska, K; Marona, H; Waszkielewicz, AM or send Email.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics