Month: January 2022

Safety of 2-Chloro-6-methylaniline. Authors Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL in AMER CHEMICAL SOC published article about in [Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L.] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA in 2020, Cited 54. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Welcome to talk about 87-63-8, If you have any questions, you can contact Dinh, AN; Maddox, SM; Vaidya, SD; Saputra, MA; Nalbandian, CJ; Gustafson, JL or send Email.. Safety of 2-Chloro-6-methylaniline

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recently I am researching about CELL LUNG-CANCER; IRREVERSIBLE INHIBITORS; FAMILY KINASES; DISCOVERY; GROWTH; RESISTANCE; PROTEIN; OPTIMIZATION; ACTIVATION; EXPRESSION, Saw an article supported by the WelchThe Welch Foundation [I-1829]; ACSAmerican Cancer Society [RSG-18-039-01-DMC]; Career Enhancement Grant through NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [P50CA07090720]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Du, GY; Rao, SM; Gurbani, D; Henning, NJ; Jiang, J; Che, JW; Yang, A; Ficarro, SB; Marto, JA; Aguirre, AJ; Sorger, PK; Westover, KD; Zhang, TH; Gray, NS. The CAS is 87-63-8. Through research, I have a further understanding and discovery of 2-Chloro-6-methylaniline. Recommanded Product: 87-63-8

SRC is a major regulator of many signaling pathways and contributes to cancer development. However, development of a selective SRC inhibitor has been challenging, and FDA-approved SRC inhibitors, dasatinib and bosutinib, are multitargeted kinase inhibitors. Here, we describe our efforts to develop a selective SRC covalent inhibitor by targeting cysteine 277 on the P-loop of SRC. Using a promiscuous covalent kinase inhibitor (CKI) SM1-71 as a starting point, we developed covalent inhibitor 15a, which discriminates SRC from other covalent targets of SM1-71 including TAK1 and FGFR1. As an irreversible covalent inhibitor, compound 15a exhibited sustained inhibition of SRC signaling both in vitro and in vivo. Moreover, 15a exhibited potent antiproliferative effects in nonsmall cell lung cancer cell lines harboring SRC activation, thus providing evidence that this approach may be promising for further drug development efforts.

Recommanded Product: 87-63-8. Bye, fridends, I hope you can learn more about C7H8ClN, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly Congested Unnatural alpha-Amino Acid Synthesis WOS:000535173500051 published article about PHASE-TRANSFER CATALYSIS; ASYMMETRIC ALKYLATION; ROUTE; ACYLPYRAZOLES; DERIVATIVES in [Murata, Yumi; Nishikata, Takashi] Yamaguchi Univ, Grad Sch Sci & Engn, Ube, Yamaguchi 7558611, Japan; [Matsumoto, Yohei; Sawamura, Jun; Yazaki, Ryo; Ohshima, Takashi] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, Fukuoka 8128582, Japan in 2020.0, Cited 65.0. SDS of cas: 95-49-8. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

Unnatural alpha-amino acids are invaluable building blocks in synthetic organic chemistry and could upgrade the function of peptides. We developed a new mode for catalytic activation of amino acid Schiff bases, serving as a platform for highly congested unnatural alpha-amino acid synthesis. The redox active copper catalyst enabled efficient cross-coupling to construct contiguous tetrasubstituted carbon centers. The broad functional group compatibility highlights the mildness of the present catalysis. Notably, we achieved successive beta-functionalization and oxidation of amino acid Schiff bases to afford dehydroalanine derivatives bearing tetrasubstituted carbon. A three-component cross-coupling reaction of an amino acid Schiff base, alkyl bromides, and styrene derivatives demonstrated the high utility of the present method. The diastereoselective reaction was also achieved using menthol derivatives as a chiral auxiliary, delivering enantiomerically enriched alpha-amino acid bearing alpha,beta-continuous tetrasubstituted carbon. The synthesized highly congested unnatural alpha-amino acid could be derivatized and incorporated into peptide synthesis.

SDS of cas: 95-49-8. Welcome to talk about 95-49-8, If you have any questions, you can contact Matsumoto, Y; Sawamura, J; Murata, Y; Nishikata, T; Yazaki, R; Ohshima, T or send Email.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recently I am researching about HIGHLY SELECTIVE OXIDATION; PLATINUM CATALYST; MOLECULAR-OXYGEN; ALLYLIC ALCOHOLS; PORE STRUCTURE; POROUS CARBON; ALDEHYDES; EFFICIENT; NANOPARTICLES; SURFACE, Saw an article supported by the Institute for Advanced Studies in Basic Science (IASBS) Research Council [G2019IASBS31100]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Formula: C7H4Cl2O2

Preparation of an ordered mesoporous polypyrrole/carbon (PPy/OMC) composite has been described through a two-step nanocasting process using KIT-6 as a template. Characterization of the PPy/OMC nanocomposite by various analysis methods such as TEM, XRD, TGA, SEM and N-2 sorption confirmed the preparation of a material with ordered mesoporous structure, uniform pore size distribution, high surface area and high stability. This nanocomposite was then used for the immobilization of palladium nanoparticles. The nanoparticles were almost uniformly distributed on the support with a narrow particle size of 20-25 nm, confirmed by various analysis methods. Performance of the Pd@PPy/OMC catalyst was evaluated in the aerobic oxidation of various primary and secondary alcohols on water as a green solvent, giving the corresponding carboxylic acids and ketones in high yields and excellent selectivity. The catalyst could also be reused for at least 10 reaction runs without losing its catalytic activity and selectivity. High catalytic efficiency of the catalyst can be attributed to a strong synergism between the PPy/OMC and that of supported Pd nanoparticles.

Welcome to talk about 50-84-0, If you have any questions, you can contact Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H or send Email.. Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Selective Solvent-Free and Additive-Free Oxidation of Primary Benzylic C-H Bonds with O-2 Catalyzed by the Combination of Metalloporphyrin with N-Hydroxyphthalimide WOS:000558395000001 published article about METAL-ORGANIC FRAMEWORKS; AEROBIC OXIDATION; CYCLOHEXANE OXIDATION; GREEN CHEMISTRY; TOLUENE; EFFICIENT; PERFORMANCE; PORPHYRINS; MANGANESE; COMPLEX in [Shen, Hai-Min; Qi, Bei; Hu, Meng-Yun; Liu, Lei; Ye, Hong-Liang; She, Yuan-Bin] Zhejiang Univ Technol, Coll Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Peoples R China in 2020, Cited 75. Formula: C7H7Cl. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

A protocol for solvent-free and additive-free oxidation of primary benzylic C-H bonds with O(2)was presented through adjusting the combination of metalloporphyrins and NHPI as binary catalysts to overcome the deficiencies encountered in current oxidation systems. The effects of reaction temperature, porphyrin structure, central metal, catalyst loading and O(2)pressure were investigated systematically. For the optimized combination of T(2-OCH3)PPCo and NHPI, all the primary benzylic C-H bonds could be functionalized efficiently and selectively at 120 degrees C and 1.0 MPa O(2)with aromatic acids as the primary products. The selectivity towards aromatic acids could reach up to 70-95% in the conversion of more than 30% for most of the substrates possessing primary benzylic C-H bonds in the metalloporphyrin loading of 0.012% (mol/mol). And the superior performance of T(2-OCH3)PPCo among the metalloporphyrins investigated was mainly attributed to its high efficiency in charge transfer and fewer positive charges around central metal Co (II) which favored the adduction of O-2 to cobalt (II) forming the high-valence metal-oxo complex followed by the production of phthalimide N-oxyl radical (PINO) and the initiation of the catalytic oxidation cycle. This work would provide not only an efficient protocol in utilization of hydrocarbons containing primary benzylic C-H bonds, but also a significant reference in the construction of more efficient C-H bonds oxidation systems Graphic Abstract The solvent-free and additive-free oxidation of primary benzylic C-H bonds with O(2)was presented through adjusting the combination of metalloporphyrins and NHPI as binary catalysts, and the highest selectivity towards aromatic acid reached up to 95.1% with the conversion of 88.5% in the optimized combination of T(2-OCH3)PPCo and NHPI. [GRAPHICS] .

Formula: C7H7Cl. Welcome to talk about 95-49-8, If you have any questions, you can contact Shen, HM; Qi, B; Hu, MY; Liu, L; Ye, HL; She, YB or send Email.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Synthesis and biological activities of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety WOS:000465007200008 published article about BACTERIAL LEAF-BLIGHT; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; 1,4-PENTADIEN-3-ONE DERIVATIVES; MOSAIC-VIRUS; DESIGN; INHIBITORS; 3D-QSAR; BETA in [Tang, Xu; Wang, Zhongbo; Zhong, Xinmin; Chen, Lijuan; He, Ming; Xue, Wei] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang, Guizhou, Peoples R China; [Wang, Xiaobin] Nanjing Agr Univ, Coll Sci, Nanjing, Jiangsu, Peoples R China in 2019, Cited 37. COA of Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

A series of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety were designed, synthesized and evaluated for their antibacterial, antifungal and antiviral activities. The bioassay results indicated that most of target compounds showed good antiviral activities against tobacco mosaic virus (TMV) and antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Ralstonia solanacearum (Rs). Especially, the anti-Xoo effect of title compounds 5k (N-(5-methoxybenzo[d]thiazol-2-yl)-2-((5-(2-tolyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) and the anti-Rs effect of title compounds 5a (N-(5-nitrobenzo[d]thiazol-2-yl)-2-((5-(4-(trifluorom ethyl)phenyl)-1,3,4-thiadiazol-2-yl)thio)acetmide) respectively reached 52.4% and 71.6% at 100 mu g/mL, which are superior to that of bismerthiazol (32.0% and 52.3%). In addition, the protective and inactivation activities of title compound 5i (N-(5-methoxybenzo [d]thiazol-2-yl)-2-((5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) against TMV were 79.5% and 88.3%, respectively, which are better than that of ningnanmycin (76.4% and 86.8%). The above research showed that benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety may be used as potential molecular templates in searching for highly-efficient antiviral and antibacterial agents.

COA of Formula: C7H4Cl2O2. Welcome to talk about 50-84-0, If you have any questions, you can contact Tang, X; Wang, ZB; Zhong, XM; Wang, XB; Chen, LJ; He, M; Xue, W or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 95-49-8. Recently I am researching about DEHYDROGENATIVE COUPLING REACTION; N-HYDROXYPHTHALIMIDE; C-O; MOLECULAR-OXYGEN; OXIDATION; FUNCTIONALIZATION; EFFICIENT; ALKANES; ALKENES; BENZYL, Saw an article supported by the Hunan Province Science Foundation for Youths [2018JJ3215]; Research Foundation of Education Bureau of Hunan Province [18C0147]; Hunan Agricultural University Science Foundation for High-Level Personnel, Double first-class construction project of Hunan Agricultural University [17QN21]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31672457]; Local Science and Technology Development Project [YDZX20184300002303]; Ministry of Agriculture of the People’s Republic of ChinaMinistry of Agriculture, China [2015-Z64, 2016-X47]; Hunan Provincial Science and Technology Department [2016NK2101, 2016WK2008, 2016TP2005, 2018CT5002]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Jiang, HM; Tang, XY; Liu, SH; Wang, L; Shen, HC; Yang, JK; Wang, HX; Gui, QW. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene

A novel, sustainable, environmentally friendly, high substrate scope, efficient, solvent-free and metal catalyst-free method for the cross-dehydrogenative coupling (CDC) reaction between N-hydroxyphthalimide (NHPI) and benzyl/ether compounds is described. This coupling reaction proceeds through ultrasound acceleration. Compared to conventional heating conditions, the use of ultrasound techniques not only improves the reaction efficiency and enhances the reaction rate but also minimizes the side reactions.

Welcome to talk about 95-49-8, If you have any questions, you can contact Jiang, HM; Tang, XY; Liu, SH; Wang, L; Shen, HC; Yang, JK; Wang, HX; Gui, QW or send Email.. Recommanded Product: 95-49-8

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019 MED CHEM published article about GLUCOSIDASE INHIBITORY-ACTIVITY; ALPHA-GLUCOSIDASE; BIOLOGICAL EVALUATION; BENZOTHIAZOLE DERIVATIVES; SULFONAMIDE; DOCKING; AMYLASE; BENZENESULFONAMIDE; AGENTS; POTENT in [Thakral, Samridhi; Singh, Vikramjeet] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Hisar 125001, Haryana, India in 2019, Cited 55. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Application In Synthesis of 2,4-Dichlorobenzoic acid

Background: Postprandial hyperglycemia can be reduced by inhibiting major carbohydrate hydrolyzing enzymes, such as alpha-glucosidase and alpha-amylase which is an effective approach in both preventing and treating diabetes. Objective: The aim of this study was to synthesize a series of 2,4-dichloro-5-[(N-and/alkyl)sulfamoyl]benzoic acid derivatives and evaluate alpha-glucosidase and alpha-amylase inhibitory activity along with molecular docking and in silico ADMET property analysis. Method: Chlorosulfonation of 2,4-dichloro benzoic acid followed by reaction with corresponding anilines/amines yielded 2,4-dichloro-5-[(N-aryl/alkyl)sulfamoyl]benzoic acid derivatives. For evaluating their antidiabetic potential alpha-glucosidase and alpha-amylase inhibitory assays were carried out. In silico molecular docking studies of these compounds were performed with respect to these enzymes and a computational study was also carried out to predict the drug-likeness and ADMET properties of the title compounds. Results: Compound 3c (2,4-clichloro-5-[(2-nitrophenyl)sulfamoyl]benzoic acid) was found to be highly active having 3 fold inhibitory potential against alpha-amylase and 5 times inhibitory activity against alpha-glucosidase in comparison to standard drug acarbose. Conclusion: Most of the synthesized compounds were highly potent or equipotent to standard drug acarbose for inhibitory potential against alpha-glucosidase and alpha-amylase enzyme and hence this may indicate their antidiabetic activity. The docking study revealed that these compounds interact with active site of enzyme through hydrogen bonding and different pi interactions.

Bye, fridends, I hope you can learn more about C7H4Cl2O2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

SDS of cas: 50-84-0. Recently I am researching about CANDIDA-ALBICANS; FUNGAL-INFECTIONS; CYP51; ASPERGILLOSIS; MECHANISMS; DIAGNOSIS; AGENTS, Saw an article supported by the Empirikion Foundation; Serbian Ministry of Education, Science and Technological Development [451-03-68/2020-14/200007]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Zoidis, G; Kritsi, E; Lecinska, P; Ivanov, M; Zoumpoulakis, P; Sokovic, M; Catto, M. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

The significant antifungal activity of a series of novel 1,2,4-triazole derivatives against different strains ofCandida albicans,Candida kruseiandAspergillus fumigatus, compared to the commercial fungicides ketoconazole and itraconazole, is reported. Systemic mycosis and invasive fungal infections, whether from immunodeficiency or hospital-acquired infection, have been on an upward trend for several years. The 1,2,4-triazole ring substituted with other aromatic and heteroaromatic systems plays an important role in the field of antifungal drug discovery and development. Thus, an extensive series of 29 triazoles, substituted in different positions with a variety of aromatic rings, has been designed, synthesized, and evaluated for their fungicidal activity. Almost all the agents testedin vitroshowed high activity against all examined fungal strains. It is noteworthy that, in the case ofA. fumigatus, all the examined compounds achieved equal or higher antifungal activity than ketoconazole, but less activity than itraconazole. Among all the derivatives studied, the dichlorourea analogue and bromo-substituted triazole stand out as the most promising compounds. Quantitative structure-activity relationship (QSAR) models were built for a systematic structure-activity relationship (SAR) profile to explain and potentially explore the potency characteristics of 1,2,4-triazole analogues.

Welcome to talk about 50-84-0, If you have any questions, you can contact Zoidis, G; Kritsi, E; Lecinska, P; Ivanov, M; Zoumpoulakis, P; Sokovic, M; Catto, M or send Email.. SDS of cas: 50-84-0

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H4Cl2O2. Mao, SY; Kramer, JH; Sun, HR in [Mao, Siyu; Kramer, Jordan H.; Sun, Haoran] Univ South Dakota, Dept Chem, Vermillion, SD 57069 USA; [Mao, Siyu; Kramer, Jordan H.; Sun, Haoran] Univ South Dakota, Ctr Fluorinated Funct Mat, Vermillion, SD 57069 USA published Deoxyfluorination of Carboxylic Acids with KF and Highly Electron-Deficient Fluoroarenes in 2021.0, Cited 48.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6.

A deoxyfluorination reaction of carboxylic acids using potassium fluoride (KF) and highly electron-deficient fluoroarenes is reported here, giving acyl fluorides in moderate to excellent yield (57-92% based on NMR integration and 34-95% for isolated examples).

HPLC of Formula: C7H4Cl2O2. Welcome to talk about 50-30-6, If you have any questions, you can contact Mao, SY; Kramer, JH; Sun, HR or send Email.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics