An article [Pd(NHC)(mu-Cl)Cl](2): Versatile and Highly Reactive Complexes for Cross-Coupling Reactions that Avoid Formation of Inactive Pd(I) Off-Cycle Products WOS:000564153700005 published article about HETEROCYCLIC CARBENE COMPLEXES; TEMPERATURE SUZUKI-MIYAURA; ARYL CHLORIDES; (NHC)PD(ALLYL)CL NHC; GENERAL-METHOD; BASIS-SETS; PALLADIUM; PRECATALYST; APPROXIMATION; DERIVATIVES in [Zhou, Tongliang; Ma, Siyue; Szostak, Michal] Rutgers State Univ, Dept Chem, 73 Warren St, Newark, NJ 07102 USA; [Nahra, Fady; Cazin, Catherine S. J.; Nolan, Steven P.] Univ Ghent, Dept Chem, Krijgslaan 281,S-3, B-9000 Ghent, Belgium; [Nahra, Fady] Univ Ghent, Ctr Sustainable Chem, Krijgslaan 281,S-3, B-9000 Ghent, Belgium; [Obled, Alan M. C.] VITO Flemish Inst Technol Res, Separat & Convers Technol Unit, Boeretang 200, B-2400 Mol, Belgium; [Poater, Albert] Univ St Andrews, EaStCHEM Sch Chem, St Andrews KY16 9ST, Fife, Scotland; [Cavallo, Luigi] Univ Girona, Inst Quim Computac & Catalisi, C Maria Aurelia Capmany 69,Campus Montilivi, Girona 17003, Catalonia, Spain; [Cavallo, Luigi] Univ Girona, Dept Quim, C Maria Aurelia Capmany 69,Campus Montilivi, Girona 17003, Catalonia, Spain; [Szostak, Michal] King Abdullah Univ Sci & Technol, KAUST Catalysis Ctr KCC, Thuwal 239556900, Saudi Arabia in 2020.0, Cited 75.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Formula: C7H7Cl
The development of more reactive, general, easily accessible, and readily avail-able Pd(II)-NHC precatalysts remains a key challenge in homogeneous catalysis. In this study, we establish air-stable NHC-Pd(II) chloro-dimers, [Pd(NHC)(mu-Cl) Cl](2), as the most reactive Pd(II)-NHC catalysts developed to date. Most crucially, compared with [Pd(NHC)(allyl)Cl] complexes, replacement of the allyl throw-away ligand with chloride allows for a more facile activation step, while effec-tively preventing the formation of off-cycle [Pd-2(mu-allyl)(mu-Cl)(NHC)(2)] products. The utility is demonstrated via broad compatibility with amide cross-coupling, Suzuki cross-coupling, and the direct, late-stage functionalization of pharmaceu-ticals. Computational studies provide key insight into the NHC-Pd(II) chloro-dimer activation pathway. A facile synthesis of NHC-Pd(II) chloro-dimers in one-pot from NHC salts is reported. Considering the tremendous utility of Pd-catalyzed cross-coupling reactions and the overwhelming success of [Pd(NHC)(allyl)Cl] precatalysts, we believe that NHC-Pd(II) chloro-dimers, [Pd(NHC)(mu-Cl)Cl](2), should be considered as go-to precatalysts of choice in cross-coupling processes.
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Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
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