Recently I am researching about OXIDATIVE STRESS; DIRECTED LIGANDS; ACETYLCHOLINESTERASE; ASSAY; ACID; SITE; DERIVATIVES; HYPOTHESIS; INHIBITOR; PROPIDIUM, Saw an article supported by the . SDS of cas: 50-84-0. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Choubey, PK; Tripathi, A; Tripathi, MK; Seth, A; Shrivastava, SK. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid
Novel N-Benzylpyrrolidine hybrids were designed, synthesized, and tested against multiple in-vitro and in-vivo parameters. Among all the synthesized molecules, 8f and 12f showed extensive inhibition against beta-secretase1 (hBACE-1), human acetylcholinesterase (hAChE) & human butyrylcholinesterase (hBuChE). These molecules are also endowed with significant AChE-peripheral anionic site (PAS) binding capability, blood-brain barrier permeability, potential disassembly of A beta aggregates along with neuroprotection ability on SHSY-5Y cell lines. Results of the Y-Maze and Morris water maze test concluded that compounds 8f and 12f ameliorated cognitive dysfunction induced by scopolamine and A beta. The ex-vivo activity was executed on rat’s brain homogenate indicating a reduction in AChE level and oxidative stress. The pharmacokinetic investigation ascertained considerable oral absorption profile of the lead 12f. The results of the in silico docking studies and molecular dynamics simulations demonstrated stable interactions of compounds 8f and 12f with the target residues of hAChE, hBuChE and hBACE-1.
SDS of cas: 50-84-0. Welcome to talk about 50-84-0, If you have any questions, you can contact Choubey, PK; Tripathi, A; Tripathi, MK; Seth, A; Shrivastava, SK or send Email.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics