Recently I am researching about HEPATOCYTE GROWTH-FACTOR; KINASE INHIBITORS; TYROSINE KINASE; FACTOR-RECEPTOR; SCATTER-FACTOR; CANCER; DISCOVERY; AMPLIFICATION; RESISTANCE; CARCINOMA, Saw an article supported by the Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK2012760]; College Students Innovation Project for the R&D of Novel Drugs [J1310032]; National College Students’ innovation and entrepreneurship training program [201810316057G]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2632018ZD09]. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Zhang, QW; Ye, ZD; Shen, C; Tie, HX; Wang, L; Shi, L. The CAS is 50-30-6. Through research, I have a further understanding and discovery of 2,6-Dichlorobenzoic acid. Safety of 2,6-Dichlorobenzoic acid
HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three cancer cell lines (A549, MCF-7, and MKN-45) were also evaluated. Most of these compounds exhibited moderate to remarkable potency. Among them, compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 +/- 0.008 mu M and it also showed excellent anticancer activity against the tested cancer cell lines at low micromolar concentration. Molecular docking verified the results and revealed the possible binding mode of the most promising compound 12n into the ATP-binding site of c-Met kinase.
Safety of 2,6-Dichlorobenzoic acid. Welcome to talk about 50-30-6, If you have any questions, you can contact Zhang, QW; Ye, ZD; Shen, C; Tie, HX; Wang, L; Shi, L or send Email.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics