Recently I am researching about CARRIER PROTEIN REDUCTASE; MYCOLIC ACID BIOSYNTHESIS; CRYSTAL-STRUCTURE; CONDENSING ENZYMES; ENOYL REDUCTASE; ACP REDUCTASE; INHA; TARGET; FAS; IDENTIFICATION, Saw an article supported by the FederEuropean Commission [12001407]; l’Agence Nationale de la Recherche (ANR) FranceFrench National Research Agency (ANR) [ANR-13-JSV5-0010-01]; Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite de Lille, Institut Pasteur de Lille, Region Hauts-de-France; Region Hauts-de-France, CNRS, Institut Pasteur de Lille; European Community (FEDER)European Commission; Ministere de l’Enseignement superieur, de la Recherche et de l’Innovation (MESRI); Lille University. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Faion, L; Djaout, K; Frita, R; Pintiala, C; Cantrelle, FX; Moune, M; Vandeputte, A; Bourbiaux, K; Piveteau, C; Herledan, A; Biela, A; Leroux, F; Kremer, L; Blaise, M; Tanina, A; Wintjens, R; Hanoulle, X; Deprez, B; Willand, N; Baulard, AR; Flipo, M. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid. Recommanded Product: 50-84-0
Mycobacterium tuberculosis (M.tb), the etiologic agent of tuberculosis, remains the leading cause of death from a single infectious agent worldwide. The emergence of drug-resistant M.tb strains stresses the need for drugs acting on new targets. Mycolic acids are very long chain fatty acids playing an essential role in the architecture and permeability of the mycobacterial cell wall. Their biosynthesis involves two fatty acid synthase (FAS) systems. Among the four enzymes (MabA, HadAB/BC, InhA and KasA/B) of the FAS-II cycle, MabA (FabG1) remains the only one for which specific inhibitors have not been reported yet. The development of a new LC-MS/MS based enzymatic assay allowed the screening of a 1280 fragment-library and led to the discovery of the first small molecules that inhibit MabA activity. A fragment from the anthranilic acid series was optimized into more potent inhibitors and their binding to MabA was confirmed by F-19 ligand-observed NMR experiments. (C) 2020 Elsevier Masson SAS. All rights reserved.
Welcome to talk about 50-84-0, If you have any questions, you can contact Faion, L; Djaout, K; Frita, R; Pintiala, C; Cantrelle, FX; Moune, M; Vandeputte, A; Bourbiaux, K; Piveteau, C; Herledan, A; Biela, A; Leroux, F; Kremer, L; Blaise, M; Tanina, A; Wintjens, R; Hanoulle, X; Deprez, B; Willand, N; Baulard, AR; Flipo, M or send Email.. Recommanded Product: 50-84-0
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics