Category: chlorides-buliding-blocks. I found the field of Chemistry very interesting. Saw the article Synthesis of novel indole derivatives containing double 1,3,4-oxadiazole moiety as efficient bactericides against phytopathogenic bacterium Xanthomonas oryzae published in 2019, Reprint Addresses Ouyang, GP (corresponding author), Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang 550025, Guizhou, Peoples R China.; Ouyang, GP; Wang, ZC (corresponding author), Guizhou Univ, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China.; Ouyang, GP; Wang, ZC (corresponding author), Drug Synthet Engn Lab Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.
A series of novel indole derivatives containing double 1,3,4-oxadiazole moiety was designed, synthesized and evaluated for their antibacterial activities in vitro. These compounds were fully characterized by H-1 NMR, C-13 NMR, and HRMS. Bioassay results indicated that most of title compounds exhibited excellent antibacterial activities against rice bacterial pathogen Xanthomonas oryzae (Xoo). For example, compounds 7d, 7h, 7i, 7j, 7k, 7l and 7m had the half-maximal effective concentration (EC50) values of 52.31, 54.12, 40.65, 38.80, 51.13, 52.75 and 50.66 mu g/mL, respectively, which was better than that of commercial product bismerthiazol (BMT) (85.18 mu g/mL). The experimental results proved that indole derivatives bearing double 1,3,4-oxadiazole unit are promising candidates for the development of new agricultural bactericides against pathogenic bacterium Xoo. [GRAPHICS] .
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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics