Month: October 2021

An article Risk assessment of volatile organic compounds (VOCs) detected in sanitary pads WOS:000477139900001 published article about EXPOSURE; DIOXINS; ABSORPTION; PRODUCTS; CHLORINE; SKIN in [Kim, Hyang Yeon; Kim, Ji-Young; Kim, Kyu-Bong] Dankook Univ, Coll Pharm, 119 Dandae Ro, Cheonan 31116, South Korea; [Lee, Jung Dae; Lee, Byung-Mu] Sungkyunkwan Univ, Coll Pharm, Div Toxicol, Suwon, South Korea; [Lee, Joo Young] Catholic Univ Korea, Coll Pharm, BK21plus Team, Bucheon, South Korea; [Bae, Ok-Nam] Hanyang Univ, Coll Pharm, Ansan, South Korea; [Choi, Yong-Kyu; Baek, Eunji; Kang, Sejin; Min, Chungsik; Seo, Kyungwon; Choi, Kihwan] Minist Food & Drug Safety, Pharmaceut & Med Devices Res Dept, Cosmet Res Team, Natl Inst Food & Drug Safety Evaluat, Osong, South Korea in 2019, Cited 112. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Formula: C7H7Cl

Disposable sanitary pads are a necessity for women’s health, but safety concerns regarding the use of these products have created anxiety. The aim of this study was to conduct a risk assessment of 74 volatile organic compounds (VOCs), which were expected to be contained within sanitary pads. Of the 74 VOCs, 50 were found in sanitary pads retailed in Korea at concentrations ranging from 0.025 to 3548.09 mu g/pad. In order to undertake a risk assessment of the VOCs, the toxicological database of these compounds in the United States Environmental Protection Agency (USEPA), Agency for Toxic Substances and Disease Registry (ATSDR), National Toxicology Program (NTP) and World Health Organization (WHO) was searched. Ethanol was found to exhibit the highest reference dose (RfD) while 1,2-dibromo-3-chloro-propane displayed the lowest RfD. Consequently, a worst-case exposure scenario was applied in this study. It was assumed that there was the use of 7.5 sanitary napkins/day for 7 days/month. In the case of panty liners or overnight sanitary napkins, the utilization of 90 panty liners/month or 21 overnight sanitary napkins/month was assumed, respectively. In addition, 43 kg, the body weight of 12 to 13-year-old young women, and 100% VOCs skin absorption were employed for risk assessment. The systemic exposure dose (SED) values were calculated ranging from 1.74 (1,1,2-trichloroethane) ng/kg/day to 144.4 (ethanol, absolute) mu g/kg/day. Uncertainty factors (UFs) were applied ranging from 10 to 100,000 in accordance with the robustness of animal or human experiments. The margin of exposure (MOE) of 34 VOCs was more than 1 (acceptable MOE > 1). Applicable carcinogenic references reported that the cancer risk of five VOCs was below 10(-6). Based on our findings, evidence indicates that the non-cancer and cancer risks associated with VOCs detected in sanitary pads currently used in South Korea do not pose an adverse health risk in women.

Formula: C7H7Cl. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Kim, HY; Lee, JD; Kim, JY; Lee, JY; Bae, ON; Choi, YK; Baek, E; Kang, S; Min, C; Seo, K; Choi, K; Lee, BM; Kim, KB or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article New N-benzhydrylpiperazine/1,3,4-oxadiazoles conjugates inhibit the proliferation, migration, and induce apoptosis in HeLa cancer cells via oxidative stress-mediated mitochondrial pathway WOS:000458822400057 published article about IN-VITRO; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; CERVICAL-CANCER; G2/M PHASE; DERIVATIVES; DISCOVERY; SYNTHASE; DOCKING; ARREST in [Khanam, Rashmin; Hejazi, Iram Iqbal; Athar, Fareeda] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India; [Kumar, Raj; Meena, Ramovatar; Rajamani, Paulraj] Jawaharlal Nehru Univ, Sch Environm Sci, New Delhi, India; [Shahabuddin, Syed] Sunway Univ, RCNMET, Sch Sci & Technol, Selangor, Malaysia; [Yadav, Nitin] Indian Inst Technol, Dept Chem, New Delhi, India; [Bhat, Asif Iqbal] Cluster Univ, Dept Chem, Sri Pratap Coll, Srinagar, Jammu & Kashmir, India in 2019, Cited 43. Safety of 2,4-Dichlorobenzoic acid. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

N-benzhydrylpiperazine and 1,3,4-oxadiazoles are pharmacologically active scaffolds which exhibits significant inhibitory growth effects against various cancer cells, however, antiproliferation effects and the underlying mechanism for inducing apoptosis for aforementioned scaffolds addressing HeLa cancer cells remains uncertain. In this study, N-benzhydrylpiperazine clubbed with 1,3,4-oxadiazoles (4a-4h) were synthesized, subsequently characterized using high resolution spectroscopic techniques and eventually evaluated for their antiproliferation potential by inducing apoptosis in HeLa cancer cells. The MTT assay screening results revealed that among all, compound 4d (N-benzhydryl-4-((5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl)methyl)piperazine) in particular, exhibited IC (50) value of 28.13 +/- 0.21g/mL and significantly inhibited the proliferation of HeLa cancer cells in concentration-dependent manner. The in vitro anticancer assays for treated HeLa cells resulted in alterations in the cell morphology, reduction in colony formation, and inhibition of cell migration in concentration-dependent treatment. Furthermore, G2/M phase arrest, variations in the nuclear morphology, degradation of chromosomal DNA confirmed the ongoing apoptosis in treated HeLa cells. Increase in the expression of cytochrome C and caspase-3 confirmed the involvement of intrinsic mitochondrial pathway regulating the cell death. Also, elevation in reactive oxygen species level and loss of mitochondrial membrane potential signified that compound 4d induced apoptosis in HeLa cells by generating the oxidative stress. Therefore, compound 4d may act as a potent chemotherapeutic agent against human cervical cancer.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Khanam, R; Kumar, R; Hejazi, II; Shahabuddin, S; Meena, R; Rajamani, P; Yadav, N; Bhat, AI; Athar, F or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Room temperature clickable coupling electron deficient amines with sterically hindered carboxylic acids for the construction of amides WOS:000597946100010 published article about CATIONIC-AMPHIPHILIC POLYMERS; PRIMARY ALCOHOLS; MEDICINAL CHEMISTS; DRUG DISCOVERY; BOND FORMATION; PEPTIDE; PHENOLS; REAGENTS; TRANSFORMATION; CONVERSION in [Liu, Jing; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 205 Luoshi Rd, Wuhan 430070, Peoples R China; [Wang, Shi-Meng] Wuchang Univ Technol, Sch Life Sci, Wuhan 430223, Peoples R China in 2020.0, Cited 86.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6. COA of Formula: C7H4Cl2O2

A method for the synthesis of difficult-to-access amides was developed through the coupling of sterically hindered carboxylic acids and electron deficient amines via SO2F2-mediated dehydration. The method feathers with broad substrate scope, mild conditions, excellent functional group compatibility and high yields. (C) 2020 Elsevier Ltd. All rights reserved.

COA of Formula: C7H4Cl2O2. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Liu, J; Wang, SM; Qin, HL or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2021 SYNTHESIS-STUTTGART published article about METHYL KETONES; INTRAMOLECULAR CYCLIZATION; ELECTROPHILIC CYCLIZATION; MICHAEL ADDITION; ACCESS; STRATEGY; ANILINES; HYDROCHLORIDE; DERIVATIVES; INDOLES in [Zhou, Xiao-Yu; Chen, Xia] Liupanshui Normal Univ, Sch Chem & Mat Engn, Liupanshui 553004, Peoples R China in 2021, Cited 63. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Category: chlorides-buliding-blocks

Iodine-catalyzed oxidative C(sp(3))-H acyloxylation of acetone with carboxylic acids has been developed. The method employs iodide-as catalyst and sodium chlorite as oxidant. Substituted benzoic acids, naphthoic acids and heteroaromatic carboxylic acids can be used, and 2-oxopropyl carboxylates are obtained with good to excellent yields.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Zhou, XY; Chen, X or concate me.. Category: chlorides-buliding-blocks

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo WOS:000526784800038 published article about NF-KAPPA-B; EXPRESSION; CELLS; INFLAMMATION; INHIBITOR; DISCOVERY; CYTOKINES; THERAPY; ANALOGS in [Hu, Yang Sheng; Han, Xu; Yu, Pei Jing; Jiao, Ming Ming; Liu, Xin Hua; Shi, Jing Bo] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China in 2020, Cited 32. Formula: C7H4Cl2O2. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0

Paeonol has been proved to have potential anti-inflammatory activity, but its clinical application is not extensive due to the poor anti-inflammatory activity (14.74% inhibitory activity at 20 mu M). In order to discover novel lead compound with high anti-inflammatory activity, series of paeonol derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. Structure-activity relationships (SARs) have been fully concluded, and finally (E)-N-(4-(2-acetyl-5-methoxyphenoxy)phenyl)-3-(3,4,5-trimet-hoxyphenyl) acrylamide (compound 1 la) was found to be the best active compound with low toxicity, which showed 96.32% inhibitory activity at 20 mu M and IC50 value of 6.96 mu M against LPS-induced over expression of nitric oxide (NO) in RAW 264.7 macrophages. Preliminary mechanism studies indicated that it could inhibit the expression of TLR4, resulting in inhibiting of NF-kappa B and MAPK pathways. Further studies have shown that compound 11a has obvious therapeutic effect against the adjuvant-induced rat arthritis model.

Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Hu, YS; Han, X; Yu, PJ; Jiao, MM; Liu, XH; Shi, JB or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

SDS of cas: 95-49-8. In 2020.0 APPL CATAL A-GEN published article about RAY-ABSORPTION SPECTROSCOPY; V2O5/TIO2 CATALYSTS; OXIDE CATALYSTS; K-EDGE; REDUCTION; NO; 1,2-DICHLOROBENZENE; VANADIUM; TIO2; SCR in [Kuma, Ryoji; Tsujiguchi, Takuya] Nippon Shokubai Co Ltd, Catalysts & Green Energy Mat Res Dept, Aboshi Ku, 992-1 Aza Nishioki, Himeji, Hyogo 6711292, Japan; [Kitano, Tomoyuki] Nippon Shokubai Co Ltd, Anal Technol Ctr, 5-8 Nishi Otabi Cho, Suita, Osaka 5640034, Japan; [Tanaka, Tsunehiro] Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Kyoto 6158510, Japan; [Tanaka, Tsunehiro] Kyoto Univ, ESICB, Kyoto 6158510, Japan in 2020.0, Cited 36.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.

V2O5/TiO2-SiO2-MoO3 (TSM) catalysts exhibit enhanced redox capabilities, but the role of each species in the mixed oxide support is not well understood. Herein, the physicochemical characteristics of molybdenum oxide in TSM were investigated using X-ray diffraction, X-ray photoelectron spectroscopy, and X-ray absorption fine structure spectroscopy, and the performance of V/TSM catalysts for the oxidative decomposition of o-chlorotoluene was examined. The V/TSM catalysts exhibited superior performances in this decomposition reaction at low temperatures. The molybdenum species were highly dispersed as Mo6+, replacing Ti4+ in the anatase TiO2 framework and forming a solid solution. The redox capability of the vanadium species in the catalyst was enhanced by electron transfer from the TSM support to vanadium, likely due to the coexistence of Mo6+ and Ti(4+ )in the TSM solid solution, which has a unique structure. These results are expected to contribute to enhancing the abatement of dioxins at low temperatures.

SDS of cas: 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Kuma, R; Kitano, T; Tsujiguchi, T; Tanaka, T or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019 CHEM COMMUN published article about DEEP EUTECTIC SOLVENT; ONE-POT; AZO-DYES; EFFICIENT DIAZOTIZATION; DIAZONIUM SALTS; ARYL AMINES; CATALYST; WATER; HALOGENATION; IODINATION in [Kamble, Sujit Suresh; Shankarling, Ganapati Subray] Inst Chem Technol, Dyestuff Technol Dept, NP Marg, Mumbai 400019, Maharashtra, India in 2019, Cited 33. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8. Formula: C7H8ClN

An environmentally benign, one-pot diazotization and coupling reaction using ChCl: tartaric acid DES at room temperature is described. The bulky tartrate ion renders stability to the diazonium salt at room temperature, also evidenced by H-1 NMR. The isolated diazonium salt is stable and active even after 192 h at room temperature.

About 2-Chloro-6-methylaniline, If you have any questions, you can contact Kamble, SS; Shankarling, GS or concate me.. Formula: C7H8ClN

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 1-Chloro-2-methylbenzene. Nguyen, OT; Ha, DD in [Oanh Thi Nguyen] Dong Thap Univ, Ctr Chem Anal, Cao Lanh, Dong Thap, Vietnam; [Duc Danh Ha] Dong Thap Univ, Fac Engn Technol, Cao Lanh, Dong Thap, Vietnam published Degradation of chlorotoluenes and chlorobenzenes by the dual-species biofilm of Comamonas testosteroni strain KT5 and Bacillus subtilis strain DKT in 2019.0, Cited 56.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.

The cooperation of Bacillus subtilis strain DKT and Comamonas testosteroni KT5 was investigated for biofilm development and toluenes and chlorobenzenes degradation. Bacillus subtilis strain DKT and C. testosteroni KT5 were co-cultured in liquid media with toluenes and chlorobenzenes to determine the degradation of these substrates and formation of dual-species biofilm used for the degradation process. Bacillus subtilis strain DKT utilized benzene, mono- and dichlorinated benzenes as carbon and energy sources. The catabolism of chlorobenzenes was via hydroxylation, in which chlorine atoms were replaced by hydroxyl groups to form catechol, followed by ring fission via the ortho-cleavage pathway. The investigation of the dual-species biofilm composed of B. subtilis DKT and C. testosteroni KT5 (a toluene and chlorotoluene-degrading isolate with low biofilm formation) showed that B. subtilis DKT synergistically promoted C. testosteroni KT5 to develop biofilm. The bacterial growth in dual-species biofilm overcame the inhibitory effects caused by monochlorobenzene and 2-chlorotoluene. Moreover, the dual-species biofilm showed effective degradability toward the mixture of these substrates. This study provides knowledge about the commensal relationships in a dual-culture biofilm for designing multispecies biofilms applied for the biodegradation of toxic organic substrates that cannot be metabolized by single-organism biofilms.

Application In Synthesis of 1-Chloro-2-methylbenzene. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Nguyen, OT; Ha, DD or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Benzylarylation of N-AllyI Anilines: Synthesis of Benzylated Indolines WOS:000468696400008 published article about C-H BONDS; HIGHLY EFFICIENT ACCESS; FREE DIRECT ALKYLATION; C(SP(3))-H BONDS; OXIDATIVE CYCLIZATION; TOLUENE DERIVATIVES; ACTIVATED ALKYNES; FUNCTIONALIZATION; CATALYSIS; SP(3) in [Huang, Wenzhong; Li, Xiulan; Song, Xuemei; Luo, Qing; Li, Yanping; Liang, Deqiang; Wang, Baoling] Kunming Univ, Dept Chem, Kunming 650214, Yunnan, Peoples R China; [Dong, Ying] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China; [Liang, Deqiang; Wang, Baoling] Yunnan Engn Technol Res Ctr Plast Films, Kunming 650214, Yunnan, Peoples R China in 2019.0, Cited 129.0. Category: chlorides-buliding-blocks. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

An unprecedented benzylic C-H functionalization of methyl arenes across unactivated alkenes is presented. In the presence of MnCl2 center dot 4H(2)O and di-tert-butyl peroxide, N-allyl anilines underwent benzylation/cyclization cascade to give benzylated indolines, which are a previously unmet synthetic goal. This protocol features simple operation, broad substrate scope, and great exo selectivity.

Category: chlorides-buliding-blocks. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Huang, WZ; Li, XL; Song, XM; Luo, Q; Li, YP; Dong, Y; Liang, DQ; Wang, BL or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H7Cl. In 2020.0 APPL ORGANOMET CHEM published article about REUSABLE CATALYST; ARYL HALIDES; PALLADIUM; VITAMIN-B-6; METABOLISM; PEPTIDES in [Bagheri, Sepideh; Pazoki, Farzane; Esfandiary, Naghmeh; Fadaei, Mohammad Mahdi; Heydari, Akbar] Tarbiat Modares Univ, Fac Sci, Dept Chem, Tehran 1411713116, Iran in 2020.0, Cited 30.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.

Vitamin B-6-Pd(II) immobilized onto magnetic nanoparticles have been successfully prepared and applied for C-Xcross-coupling reactions with aryl halides in green deep eutectic solvents. The results prove that the Fe3O4@vitamin B-6-Pd(II) magnetic nanoparticles show high catalyst activity and good stability. It was also revealed that this complex can be recycled up to five times without any significant loss in catalytic activity.

HPLC of Formula: C7H7Cl. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Bagheri, S; Pazoki, F; Esfandiary, N; Fadaei, MM; Heydari, A or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics