Month: October 2021

Product Details of 50-84-0. Recently I am researching about ANTITUMOR EVALUATION; PROTEIN-LEVELS; GINSENG; SEMISYNTHESIS; APOPTOSIS; CANCER, Saw an article supported by the National Key R&D Program of China [2017YFC1702302]; Technology Platform of Industrialization Chromatographic Preparation for Standard Extract of Traditional Chinese Medicine [2010ZX09401-304-105B]; Construction of R&D institute of state original new drugs at Benxi of Liaoning Province [2009ZX09301-012-105B]; Liaoning (FGW) Engineering Technology Research Center for industrial chromatographic preparation of natural innovative drugs materials [2017-1007]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Xiao, SN; Lin, Z; Wang, XD; Lu, JC; Zhao, YQ. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

In this study, 13 panaxadiol (PD) derivatives were synthesized via reactions with aromatic compounds and amino acids. Following this, the cytotoxicity of these compounds was evaluated against four cancer cell lines (human hepatoma cells HepG-2, human lung cancer cells A549, human breast cancer cells MCF-7, and human colon cancer cells HCT-116) and one normal cell lines (human gastric epithelial cells GES-1). The results showed that the panaxadiol derivatives 3, 12, and 13 showed significant inhibition of cellular proliferation against cancer cells compared with PD, and the panaxadiol derivative 12 had the lowest IC50 value for A549 (IC50=18.91 +/- 1.03 mu m). For MCF-7 cells, most compounds exhibited good inhibition of cellular proliferation, and the panaxadiol derivative 13 showed the strongest inhibitory effect (IC50=8.62 +/- 0.23 mu m), which significantly increased the cytotoxicity of PD and was stronger than the positive control (mitomycin). For normal cells, all compounds exhibited low or no toxic effects; thus, these derivatives can be used to develop novel antiproliferative agents.

Product Details of 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Xiao, SN; Lin, Z; Wang, XD; Lu, JC; Zhao, YQ or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocks. I found the field of Chemistry very interesting. Saw the article C(sp(3))-H activation-enabled cross-coupling of two aryl halides: an approach to 9,10-dihydrophenanthrenes published in 2020, Reprint Addresses Zhang, YH (corresponding author), Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Sustainabil, 1239 Siping Rd, Shanghai 200092, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.

A palladium-catalyzed cross-coupling reaction of aryl halides with 2-chlorobenzoic acids has been developed. The reaction forms C(sp(3)), C(sp(2))-palladacycles through C(sp(3))-H activation. The palladacycles react with 2-chlorobenzoic acids through two successive C-C cross-couplings, and two C-C bonds are formed with high chemoselectivity. The reaction provides an innovative method for the synthesis of 9,10-dihydrophenanthrenes.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Gu, YC; Sun, XL; Wan, B; Lu, ZE; Zhang, YH or concate me.. Category: chlorides-buliding-blocks

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Room temperature clickable coupling electron deficient amines with sterically hindered carboxylic acids for the construction of amides published in 2020.0. COA of Formula: C7H4Cl2O2, Reprint Addresses Qin, HL (corresponding author), Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 205 Luoshi Rd, Wuhan 430070, Peoples R China.. The CAS is 50-30-6. Through research, I have a further understanding and discovery of 2,6-Dichlorobenzoic acid

A method for the synthesis of difficult-to-access amides was developed through the coupling of sterically hindered carboxylic acids and electron deficient amines via SO2F2-mediated dehydration. The method feathers with broad substrate scope, mild conditions, excellent functional group compatibility and high yields. (C) 2020 Elsevier Ltd. All rights reserved.

About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Liu, J; Wang, SM; Qin, HL or concate me.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

COA of Formula: C7H4Cl2O2. In 2020 ORG LETT published article about C-H/O-H; (ELECTRON-DEFICIENT ETA(5)-CYCLOPENTADIENYL)RHODIUM(III) CATALYST; BENZOIC-ACIDS; CARBOXYLIC-ACIDS; OXIDATIVE ANNULATION; NATURAL-PRODUCTS; ACTIVATION/ALKYNE ANNULATION; WEAK COORDINATION; ALPHA-PYRONES; N BOND in [Mihara, Gen; Ghosh, Koushik; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan; [Nishii, Yuji] Osaka Univ, Grad Sch Engn, Frontier Res Base Global Young Researchers, Suita, Osaka 5650871, Japan in 2020, Cited 66. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Transition-metal-catalyzed activation of inert C-H bonds and subsequent C-C bond formation have emerged as powerful synthetic tools for the synthesis of elaborate cyclic molecules. In this report, we introduce an efficient synthetic method of 3,4-unsubstituted isocoumarins adopting an electron-deficient (CpRh)-Rh-E complex as the catalyst. The use of vinylene carbonate as a vinylene transfer reagent enables the direct construction of isocoumarins from readily available benzoic acids, without any external oxidants as well as bases. The reaction mechanism is evaluated by computational analysis to find an unprecedented rhodium shift event within the catalytic cycle.

COA of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Mihara, G; Ghosh, K; Nishii, Y; Miura, M or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Bis-salophen palladium complex immobilized on Fe3O4@SiO2 nanoparticles as a highly active and durable phosphine-free catalyst for Heck and copper-free Sonogashira coupling reactions published in 2019.0. Quality Control of 1-Chloro-2-methylbenzene, Reprint Addresses Sardarian, AR (corresponding author), Shiraz Univ, Dept Chem, Coll Sci, Shiraz 7194684795, Iran.. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene

New Fe3O4@SiO2 core-shell superparamagnetic nanoparticles functionalized by a bis-salophen Schiff base Pd complex were synthesized and employed as an efficient magnetic nanocatalyst in the Heck and Sonogashira cross coupling reactions. The synthesized nanostructures were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), dynamic light scattering (DLS), energy dispersive X-ray analysis (EDX), X-ray photoelectron spectroscopy (XPS), elemental analysis (CHN), cyclic voltammetry (CV), Brunauer-Emmett-Teller analysis (BET), and UV-vis spectroscopy. The morphology and size of the nanoparticles were investigated by FE-SEM and TEM analyses. Furthermore, the magnetic properties of the catalyst were investigated by VSM analysis. The loading content and leaching amounts of palladium on the catalyst were measured by inductively coupled plasma (ICP) analysis. Also, the thermal behavior of this magnetic heterogeneous catalyst was studied using a TGA instrument. This heterogeneous catalytic system showed a good performance in the coupling of aryl halides with alkynes (Sonogashira reaction) as well as aryl halides with alkene derivatives (Heck reaction). High to excellent yields were achieved for these C-C coupling reactions. The catalyst can be simply separated from the reaction media by an external magnet and reused for eight consecutive runs without any significant loss of activity. Finally, the kinetics of the reactions were studied in this work.

Quality Control of 1-Chloro-2-methylbenzene. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Sardarian, AR; Kazemnejadi, M; Esmaeilpour, M or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. In 2021 J MOL STRUCT published article about PROTON-TRANSFER COMPOUNDS; SOLID-STATE LANDSCAPE; CRYSTAL-STRUCTURE; STRUCTURAL-CHARACTERIZATION; PHARMACEUTICAL COCRYSTALS; MOLECULAR-STRUCTURE; ORGANIC SALTS; SOLUBILITY; SYNTHON; ARCHITECTURES in [Chen, Bin; Wu, Ronghui; Jin, Shouwen; Bai, Liqun] Zhejiang A&F Univ, Linan 311300, Peoples R China; [Chen, Bin; Lin, Zhihao; Jin, Shouwen; Dong, Lingfeng; Xu, Weiqiang] Zhejiang A&F Univ, Jiyang Coll, Zhuji 311800, Zhejiang, Peoples R China; [Wang, Daqi] Liaocheng Univ, Dept Chem Engn, Liaocheng 252059, Shandong, Peoples R China in 2021, Cited 86. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Cocrystallization of the widely available 4-dimethylaminopyridine, with a series of carboxylic acids gave nine molecular adducts 4-dimethylaminopyridinium trifluoroacetate (1) , 4-dimethylaminopyridinium glycolate glycolic acid (2) , 4-dimethylaminopyridinium 2-furoate dihydrate (3) , tri(4-dimethylaminopyridinium) tri(o-chlorobenzoate) tetrahydrate (4) , 4-dimethylaminopyridinium 4-bromobenzoate 4-bromobenzoic acid (5) , 4-dimethylaminopyridinium 4-formylbenzoate 4-formylbenzoic acid (6) , 4-dimethylaminopyridinium 2,4-dichlorobenzoate (7) , 4-dimethylaminopyridinium 2-aminobenzoate 2-aminobenzoic acid (8) and bis(4-dimethylaminopyridinium) 5-nitroisophthalate 5-nitroisophthalic acid methanol solvate (9) . The nine adducts have been characterised by X-ray diffraction, IR and elemental analysis, the melting points were also reported. Their structural and supramolecular aspects are fully analyzed. The result reveals that among the nine investigated crystals only the ring Ns in the 4-dimethylaminopyridine moieties are protonated when the carboxylic acids are deprotonated. The crystal packing is interpreted by the strong charge-assisted N-H center dot center dot center dot O hydrogen bond between the NH+ and the deprotonated acidic groups. Except the N-H center dot center dot center dot O hydrogen bonds, the charge assisted or neutral O-H center dot center dot center dot O hydrogen bonds were also found at 2-6, 8 and 9 . The COOH center dot center dot center dot COO- synthon has been at 2, 5-6 and 8-9. Further analysis of the crystal packing indicated that a different family of additional CH-O/CH2-O/CH3-O, F-F, Br-Br, CH-Cl, CH3-Cl, CH-pi/CH3-pi, C-H center dot center dot center dot C-pi, C-pi, Cl-O, O-C, O-pi and pi-pi contacts contribute to the stabilization and expansion of the total high-dimensional (2D-3D) framework structures. For the synergism of the various nonbonding contacts there created homo/hetero supramolecular synthons or both. (C) 2021 Elsevier B.V. All rights reserved.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Chen, B; Lin, ZH; Wu, RH; Jin, SW; Dong, LF; Bai, LQ; Xu, WQ; Wang, DQ or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Meijer, FA; Doveston, RG; de Vries, RMJM; Vos, GM; Vos, AAA; Leysen, S; Scheepstra, M; Ottmann, C; Milroy, LG; Brunsveld, L in [Meijer, Femke A.; Doveston, Richard G.; de Vries, Rens M. J. M.; Vos, Gael M.; Vos, Alex A. A.; Leysen, Seppe; Scheepstra, Marcel; Ottmann, Christian; Milroy, Lech-Gustav; Brunsveld, Luc] Tech Univ Eindhoven, Lab Chem Biol, Dept Biomed Engn, Dolech 2, NL-5612 AZ Eindhoven, Netherlands; [Meijer, Femke A.; Doveston, Richard G.; de Vries, Rens M. J. M.; Vos, Gael M.; Vos, Alex A. A.; Leysen, Seppe; Scheepstra, Marcel; Ottmann, Christian; Milroy, Lech-Gustav; Brunsveld, Luc] Tech Univ Eindhoven, Inst Complex Mol Syst, Dolech 2, NL-5612 AZ Eindhoven, Netherlands; [Doveston, Richard G.] Univ Leicester, Leicester Inst Struct & Chem Biol, Univ Rd, Leicester LE1 7RH, Leics, England; [Doveston, Richard G.] Univ Leicester, Dept Chem, Univ Rd, Leicester LE1 7RH, Leics, England published Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor gamma t (ROR gamma t) Inverse Agonists in 2020.0, Cited 52.0. COA of Formula: C7H4Cl2O2. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6.

Retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) is a nuclear receptor associated with the pathogenesis of autoimmune diseases. Allosteric inhibition of ROR gamma t is conceptually new, unique for this specific nuclear receptor, and offers advantages over traditional orthosteric inhibition. Here, we report a highly efficient in silico-guided approach that led to the discovery of novel allosteric ROR gamma t inverse agonists with a distinct isoxazole chemotype. The the most potent compound, 25 (FM26), displayed submicromolar inhibition in a coactivator recruitment assay and effectively reduced IL-17a mRNA production in EM cells, a marker of ROR gamma t activity. The projected allosteric mode of action of 25 was confirmed by biochemical experiments and cocrystallization with the ROR gamma t ligand binding domain. The isoxazole compounds have promising pharmacokinetic properties comparable to other allosteric ligands but with a more diverse chemotype. The efficient ligand-based design approach adopted demonstrates its versatility in generating chemical diversity for allosteric targeting of ROR gamma t.

About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Meijer, FA; Doveston, RG; de Vries, RMJM; Vos, GM; Vos, AAA; Leysen, S; Scheepstra, M; Ottmann, C; Milroy, LG; Brunsveld, L or concate me.. COA of Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Formula: C7H4Cl2O2. In 2020 BIOORG CHEM published article about NF-KAPPA-B; EXPRESSION; CELLS; INFLAMMATION; INHIBITOR; DISCOVERY; CYTOKINES; THERAPY; ANALOGS in [Hu, Yang Sheng; Han, Xu; Yu, Pei Jing; Jiao, Ming Ming; Liu, Xin Hua; Shi, Jing Bo] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China in 2020, Cited 32. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

Paeonol has been proved to have potential anti-inflammatory activity, but its clinical application is not extensive due to the poor anti-inflammatory activity (14.74% inhibitory activity at 20 mu M). In order to discover novel lead compound with high anti-inflammatory activity, series of paeonol derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. Structure-activity relationships (SARs) have been fully concluded, and finally (E)-N-(4-(2-acetyl-5-methoxyphenoxy)phenyl)-3-(3,4,5-trimet-hoxyphenyl) acrylamide (compound 1 la) was found to be the best active compound with low toxicity, which showed 96.32% inhibitory activity at 20 mu M and IC50 value of 6.96 mu M against LPS-induced over expression of nitric oxide (NO) in RAW 264.7 macrophages. Preliminary mechanism studies indicated that it could inhibit the expression of TLR4, resulting in inhibiting of NF-kappa B and MAPK pathways. Further studies have shown that compound 11a has obvious therapeutic effect against the adjuvant-induced rat arthritis model.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Hu, YS; Han, X; Yu, PJ; Jiao, MM; Liu, XH; Shi, JB or concate me.. Formula: C7H4Cl2O2

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Characterization of luminescent hydroxyapatite@terbium complex core-shell composites using chlorobenzoic acid as ligands WOS:000574747900003 published article about NANOCOMPOSITES; NANOCRYSTAL in [Jiang, Guangpeng; Song, Lulu; Tao, Dongliang; Jin, Feng] Fuyang Normal Univ, Coll Chem & Mat Engn, Fuyang 236037, Peoples R China in 2020, Cited 29. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Safety of 2,4-Dichlorobenzoic acid

Three kinds of novel hydroxyapatite@terbium complex core-shell composites were synthesized with 2-chlorobenzoic acid, 4-chlorobenzoic acid, and 2,4-dichlorobenzoic acid as the ligand, respectively. The XRD, UV/vis absorption and FT-IR results show that terbium ions are coordinated with ligands and the corresponding complexes are successfully included into composites. SEM and EDS results reveal that Tb complexes are fully and homogenously coated on the surface of hydroxyapatite (HAP) microspheres consisting of a large number of nanosized crystals. The strongest luminescence properties are obtained when 2,4-dichlorobenzoic acid is used as ligand. The study on fluorescence lifetime of composites shows that the lifetime is inversely related to emission intensity. TGA-DSC results indicate that the core-shell composites have an excellent thermal stability. Therefore, the current core-shell structure provides a cost-effective route to manufacture of biocompatible and heat-resistant highly luminescent materials. (C) 2020 Chinese Society of Rare Earths. Published by Elsevier B.V. All rights reserved.

About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Jiang, GP; Song, LL; Tao, DL; Jin, F or concate me.. Safety of 2,4-Dichlorobenzoic acid

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In 2019 PHOSPHORUS SULFUR published article about BACTERIAL LEAF-BLIGHT; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; 1,4-PENTADIEN-3-ONE DERIVATIVES; MOSAIC-VIRUS; DESIGN; INHIBITORS; 3D-QSAR; BETA in [Tang, Xu; Wang, Zhongbo; Zhong, Xinmin; Chen, Lijuan; He, Ming; Xue, Wei] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine Chem, Guiyang, Guizhou, Peoples R China; [Wang, Xiaobin] Nanjing Agr Univ, Coll Sci, Nanjing, Jiangsu, Peoples R China in 2019, Cited 37. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Formula: C7H4Cl2O2

A series of benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety were designed, synthesized and evaluated for their antibacterial, antifungal and antiviral activities. The bioassay results indicated that most of target compounds showed good antiviral activities against tobacco mosaic virus (TMV) and antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Ralstonia solanacearum (Rs). Especially, the anti-Xoo effect of title compounds 5k (N-(5-methoxybenzo[d]thiazol-2-yl)-2-((5-(2-tolyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) and the anti-Rs effect of title compounds 5a (N-(5-nitrobenzo[d]thiazol-2-yl)-2-((5-(4-(trifluorom ethyl)phenyl)-1,3,4-thiadiazol-2-yl)thio)acetmide) respectively reached 52.4% and 71.6% at 100 mu g/mL, which are superior to that of bismerthiazol (32.0% and 52.3%). In addition, the protective and inactivation activities of title compound 5i (N-(5-methoxybenzo [d]thiazol-2-yl)-2-((5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)thio)acetamide) against TMV were 79.5% and 88.3%, respectively, which are better than that of ningnanmycin (76.4% and 86.8%). The above research showed that benzothiazole derivatives bearing a 1,3,4-thiadiazole moiety may be used as potential molecular templates in searching for highly-efficient antiviral and antibacterial agents.

Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Tang, X; Wang, ZB; Zhong, XM; Wang, XB; Chen, LJ; He, M; Xue, W or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics