Month: October 2021

Recommanded Product: 87-63-8. In 2020 ORG LETT published article about ARYLATION; ALKYNES; INDOLOQUINOLINES; ACTIVATION; ACCESS; HYDROARYLATION; ANNULATION; ALKALOIDS in [Chen, Chen; Wang, Yuebo; Shi, Xiaonan; Sun, Wan; Zhao, Jinghui; Liu, Liying; Zhu, Bolin] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Peiformance Funct Mol, Tianjin 300387, Peoples R China; [Zhu, Yan-Ping] Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Shandong, Peoples R China in 2020, Cited 56. The Name is 2-Chloro-6-methylaniline. Through research, I have a further understanding and discovery of 87-63-8.

Here we report a protocol to synthesize diversiform fluorinated isocryptolepine analogues with potential biological activities in one step via directed C-2 and C-3 dual C-H functionalization of indoles. We also attempted to take into account fluorinated imidoyl chlorides as a novel kind of synthons in the directed C-H functionalization reactions. As a result, a variety of fluorinated isocryptolepine analogues were obtained in up to 96% yield. Moreover, we conducted control experiments to disclose the reaction mechanism.

Recommanded Product: 87-63-8. About 2-Chloro-6-methylaniline, If you have any questions, you can contact Chen, C; Wang, YB; Shi, XN; Sun, W; Zhao, JH; Zhu, YP; Liu, LY; Zhu, BL or concate me.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/20879; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Authors Chauhan, S; Verma, P; Kandasamy, J; Srivastava, V in WILEY-V C H VERLAG GMBH published article about PRIVILEGED SCAFFOLD; MEDIATED SYNTHESIS; DERIVATIVES; HYDROPEROXIDE; TBHP; METHYLARENES; ACTIVATION; ENAMINES; TOLUENE; AGENTS in [Chauhan, Swati; Verma, Pratibha; Kandasamy, Jeyakumar; Srivastava, Vandana] Indian Inst Technol BHU, Dept Chem, Varanasi 221005, Uttar Pradesh, India in 2020.0, Cited 48.0. Safety of 1-Chloro-2-methylbenzene. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

An efficient synthesis of 3-functionalized coumarins is demonstrated fromo-cresols and active methylene compounds under solvent-, metal- and catalyst-free conditions in the presence of 70 % aqueoustert-butyl hydrogen peroxide. The important features of this protocol are operational simplicity, mild reaction conditions and good to excellent yield of the products.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Chauhan, S; Verma, P; Kandasamy, J; Srivastava, V or concate me.. Safety of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: C7H4Cl2O2. Recently I am researching about GROUP-11 METAL(I) COMPOUNDS; COPPER-CATALYZED SYNTHESIS; LEWIS-BASE ADDUCTS; STEREOSELECTIVE-SYNTHESIS; NITROGEN ANALOGS; ROOM-TEMPERATURE; CARBOXYLIC-ACIDS; AMIDE SYNTHESIS; FACILE ACCESS; ALKYNE, Saw an article supported by the NNSFCNational Natural Science Foundation of China (NSFC) [21472107, 21372142]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Yang, WG; Huang, DY; Zeng, XB; Zhang, JL; Wang, XY; Hu, YF. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from an ynone-participated CuAAC/ring-opening method. Its unique structure allowed it to react with aryl carboxylic acids to give N-aroylsulfonamides via a novel Mumm-type rearrangement. (C) 2018 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Yang, WG; Huang, DY; Zeng, XB; Zhang, JL; Wang, XY; Hu, YF or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits published in 2019. Computed Properties of C7H4Cl2O2, Reprint Addresses Overkleeft, HS (corresponding author), Leiden Inst Chem, Gorlaeus Labs, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.; Overkleeft, HS (corresponding author), Netherlands Prote Ctr, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.; Groll, M (corresponding author), Tech Univ Munich, Lehrstuhl Biochem, Dept Chem, Ctr Integrated Prot Sci, D-85748 Garching, Germany.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid

Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the beta 1c, beta 1i, beta 5c, and beta 5i subunits exploit the differences in the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting beta 2c or beta 2i could not yet be rationally designed because of the high structural similarity of these two subunits. Here, we report the development, chemical synthesis, and biological screening of a compound library that led to the identification of the beta 2c- and beta 2i-selective-compounds LU-002c (4; IC50 beta 2c: 8 nM, IC50 beta 2i/beta 2c: 40-fold) and LU-002i (5; IC50 beta 2i: 220 nM, IC50 beta 2c/beta 2i: 45-fold), respectively. Co-crystal structures with beta 2 humanized yeast proteasomes visualize protein-ligand interactions crucial for subunit specificity. Altogether, organic syntheses, activity-based protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant differences of beta 2 substrate-binding channels and to complete the set of subunit-selective proteasome inhibitors.

Computed Properties of C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, YM; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents WOS:000600384300038 published article about APOPTOSIS; ORIDONIN; DITERPENOIDS; ANALOGS; CANCER; INHIBITION in [Huo, Jun-Feng; Hu, Tian-Xing; Dong, Ya-Long; Zhao, Jin-Zhu; Liu, Xiao-Jie; Li, Lei-Lei; Zhang, Xue-Yan; Li, Yun-Fan; Liu, Hong-Min; Ke, Yu; Wang, Cong] Zhengzhou Univ, Sch Pharmaceut Sci, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450001, Henan, Peoples R China; [Huo, Jun-Feng; Hu, Tian-Xing; Dong, Ya-Long; Zhao, Jin-Zhu; Liu, Xiao-Jie; Li, Lei-Lei; Zhang, Xue-Yan; Li, Yun-Fan; Liu, Hong-Min; Ke, Yu; Wang, Cong] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou 450001, Henan, Peoples R China in 2020, Cited 46. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0. Product Details of 50-84-0

As our research focuses on anticancer drugs, a series of novel derivatives of flexicaulin A (FA), an ent-kaurene diterpene, condensed with an aromatic ring were synthesized, and their antiproliferative activities against four human cancer cell lines (TE-1, EC109, MCF-7, and MGC-803) were evaluated. The activities of most of the new compounds were better than those of FA. Compound 2y exhibited the best activity with an IC50 value reaching 0.13 mu M against oesophageal cancer cells (EC109 cells). The IC50 values for 2y in normal cells (GES-1 cells and HUVECs) were 0.52 mu M and 0.49 mu M, respectively. Subsequent mechanistic investigations found that compound 2y can inhibit the proliferation of cancer cells and cell cloning. In addition, 2y could reduce the mitochondrial membrane potential, increase the apoptosis rate, and increase the ROS level in EC109 cells. Moreover, 2y can upregulate the expression of ROS/JNK pathway-related proteins (p-ASK1, p-MKK4, p-JNK, and p-Cjun (ser63)) and pro-apoptotic proteins (Bax, Bad, and Bim). In vivo experiments showed that 2y can inhibit tumour growth in nude mice. The mechanism involves an increase in protein expression in the ROS pathway, leading to changes in apoptosis-related proteins. In addition, compound 2y shows low toxicity. These results indicate that compound 2y holds promising potential as an antiproliferative agent. (c) 2020 Elsevier Masson SAS. All rights reserved.

Product Details of 50-84-0. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Huo, JF; Hu, TX; Dong, YL; Zhao, JZ; Liu, XJ; Li, LL; Zhang, XY; Li, YF; Liu, HM; Ke, Y; Wang, C or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,6-Dichlorobenzoic acid. In 2019.0 J ENZYM INHIB MED CH published article about HEPATOCYTE GROWTH-FACTOR; KINASE INHIBITORS; TYROSINE KINASE; FACTOR-RECEPTOR; SCATTER-FACTOR; CANCER; DISCOVERY; AMPLIFICATION; RESISTANCE; CARCINOMA in [Zhang, Qing-Wen; Ye, Zi-Dan; Shen, Chang; Tie, Hong-Xia; Wang, Lei; Shi, Lei] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Jiangsu, Peoples R China in 2019.0, Cited 31.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6.

HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three cancer cell lines (A549, MCF-7, and MKN-45) were also evaluated. Most of these compounds exhibited moderate to remarkable potency. Among them, compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 +/- 0.008 mu M and it also showed excellent anticancer activity against the tested cancer cell lines at low micromolar concentration. Molecular docking verified the results and revealed the possible binding mode of the most promising compound 12n into the ATP-binding site of c-Met kinase.

Safety of 2,6-Dichlorobenzoic acid. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Zhang, QW; Ye, ZD; Shen, C; Tie, HX; Wang, L; Shi, L or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Photocatalytic (Het)arylation of C(sp(3))-H Bonds with Carbon Nitride WOS:000618540300047 published article about C-H BONDS; LIGHT PHOTOREDOX CATALYSIS; HYDROGEN-PRODUCTION; FUNCTIONALIZATION; ARYLATION; PHOTOCHEMISTRY; ALKYLATION; CO2 in [Das, Saikat; Murugesan, Kathiravan; Rodriguez, Gonzalo J. Villegas; Kaur, Jaspreet; Barham, Joshua P.; Koenig, Burkhard] Univ Regensburg, Fak Chem & Pharm, D-93040 Regensburg, Germany; [Savateev, Aleksandr; Antonietti, Markus] Max Planck Inst Colloids & Interfaces, Dept Colloid Chem, D-14424 Potsdam, Germany in 2021.0, Cited 74.0. HPLC of Formula: C7H7Cl. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

Graphitic carbon nitride materials have attracted significant interest in recent years and found applications in diverse light-to-energy conversions such as artificial photosynthesis, CO2 reduction, or degradation of organic pollutants. However, their utilization in synthetic photocatalysis, especially in the direct functionalization of C(sp(3))-H bonds, remains underexplored. Herein, we report mesoporous graphitic carbon nitride (mpg-CN as a heterogeneous organic semiconductor photocatalyst for direct arylation of C(sp(3))-H bonds in combination with nickel catalysis. Our protocol has a broad synthetic scope (>70 examples including late-stage functionalization of drugs and agrochemicals), is operationally simple, and shows high chemo- and regioselectivities. Facile separation and recycling of the mpg-CN catalyst in combination with its low preparation cost, innate photochemical stability, and low toxicity are beneficial features overcoming typical shortcomings of homogeneous photocatalysis. Detailed mechanistic investigations and kinetic studies indicate that an unprecedented energy-transfer process (EnT) from the organic semiconductor to the nickel complex is operating.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Das, S; Murugesan, K; Rodriguez, GJV; Kaur, J; Barham, JP; Savateev, A; Antonietti, M; Konig, B or concate me.. HPLC of Formula: C7H7Cl

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C7H7Cl. Authors Li, JP; Huang, CY; Wen, DH; Zheng, QS; Tu, B; Tu, T in AMER CHEMICAL SOC published article about in [Li, Jinpeng; Huang, Changyu; Wen, Daheng; Zheng, Qingshu; Tu, Bo; Tu, Tao] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200438, Peoples R China; [Tu, Tao] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China; [Tu, Tao] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China; [Tu, Tao] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China in 2021, Cited 33. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Li, JP; Huang, CY; Wen, DH; Zheng, QS; Tu, B; Tu, T or concate me.. Formula: C7H7Cl

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 1-Chloro-2-methylbenzene. In 2020.0 APPL CATAL A-GEN published article about RAY-ABSORPTION SPECTROSCOPY; V2O5/TIO2 CATALYSTS; OXIDE CATALYSTS; K-EDGE; REDUCTION; NO; 1,2-DICHLOROBENZENE; VANADIUM; TIO2; SCR in [Kuma, Ryoji; Tsujiguchi, Takuya] Nippon Shokubai Co Ltd, Catalysts & Green Energy Mat Res Dept, Aboshi Ku, 992-1 Aza Nishioki, Himeji, Hyogo 6711292, Japan; [Kitano, Tomoyuki] Nippon Shokubai Co Ltd, Anal Technol Ctr, 5-8 Nishi Otabi Cho, Suita, Osaka 5640034, Japan; [Tanaka, Tsunehiro] Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Kyoto 6158510, Japan; [Tanaka, Tsunehiro] Kyoto Univ, ESICB, Kyoto 6158510, Japan in 2020.0, Cited 36.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.

V2O5/TiO2-SiO2-MoO3 (TSM) catalysts exhibit enhanced redox capabilities, but the role of each species in the mixed oxide support is not well understood. Herein, the physicochemical characteristics of molybdenum oxide in TSM were investigated using X-ray diffraction, X-ray photoelectron spectroscopy, and X-ray absorption fine structure spectroscopy, and the performance of V/TSM catalysts for the oxidative decomposition of o-chlorotoluene was examined. The V/TSM catalysts exhibited superior performances in this decomposition reaction at low temperatures. The molybdenum species were highly dispersed as Mo6+, replacing Ti4+ in the anatase TiO2 framework and forming a solid solution. The redox capability of the vanadium species in the catalyst was enhanced by electron transfer from the TSM support to vanadium, likely due to the coexistence of Mo6+ and Ti(4+ )in the TSM solid solution, which has a unique structure. These results are expected to contribute to enhancing the abatement of dioxins at low temperatures.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Kuma, R; Kitano, T; Tsujiguchi, T; Tanaka, T or concate me.. Quality Control of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Bis-salophen palladium complex immobilized on Fe3O4@SiO2 nanoparticles as a highly active and durable phosphine-free catalyst for Heck and copper-free Sonogashira coupling reactions WOS:000460780300033 published article about SCHIFF-BASE COMPLEX; SUZUKI-MIYAURA; MAGNETIC NANOPARTICLES; SUPPORTED-PALLADIUM; HETEROGENEOUS CATALYST; FE3O4 NANOPARTICLES; EFFICIENT CATALYST; MIZOROKI-HECK; 5-SUBSTITUTED 1H-TETRAZOLES; RECOVERABLE CATALYSTS in [Sardarian, Ali Reza; Kazemnejadi, Milad; Esmaeilpour, Mohsen] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 7194684795, Iran in 2019.0, Cited 72.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Safety of 1-Chloro-2-methylbenzene

New Fe3O4@SiO2 core-shell superparamagnetic nanoparticles functionalized by a bis-salophen Schiff base Pd complex were synthesized and employed as an efficient magnetic nanocatalyst in the Heck and Sonogashira cross coupling reactions. The synthesized nanostructures were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), dynamic light scattering (DLS), energy dispersive X-ray analysis (EDX), X-ray photoelectron spectroscopy (XPS), elemental analysis (CHN), cyclic voltammetry (CV), Brunauer-Emmett-Teller analysis (BET), and UV-vis spectroscopy. The morphology and size of the nanoparticles were investigated by FE-SEM and TEM analyses. Furthermore, the magnetic properties of the catalyst were investigated by VSM analysis. The loading content and leaching amounts of palladium on the catalyst were measured by inductively coupled plasma (ICP) analysis. Also, the thermal behavior of this magnetic heterogeneous catalyst was studied using a TGA instrument. This heterogeneous catalytic system showed a good performance in the coupling of aryl halides with alkynes (Sonogashira reaction) as well as aryl halides with alkene derivatives (Heck reaction). High to excellent yields were achieved for these C-C coupling reactions. The catalyst can be simply separated from the reaction media by an external magnet and reused for eight consecutive runs without any significant loss of activity. Finally, the kinetics of the reactions were studied in this work.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Sardarian, AR; Kazemnejadi, M; Esmaeilpour, M or concate me.. Safety of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics