SDS of cas: 95-49-8. Huang, LB; Ackerman, LKG; Kang, K; Parsons, AM; Weix, DJ in [Huang, Liangbin; Kang, Kai; Weix, Daniel J.] Univ Wisconsin, Madison, WI 53706 USA; [Ackerman, Laura K. G.; Parsons, Astrid M.] Univ Rochester, 601 Elmwood Ave, Rochester, NY 14627 USA; [Huang, Liangbin] South China Univ Technol, Dept Chem, Guangzhou 510641, Guangdong, Peoples R China; [Ackerman, Laura K. G.] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA published LiCl-Accelerated Multimetallic Cross-Coupling of Aryl Chlorides with Aryl Triflates in 2019.0, Cited 72.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.
While the synthesis of biaryls has advanced rapidly in the past decades, cross-Ullman couplings of aryl chlorides, the most abundant aryl electrophiles, have remained elusive. Reported here is the first general cross-Ullman coupling of aryl chlorides with aryl triflates. The selectivity challenge associated with coupling an inert electrophile with a reactive one is overcome using a multimetallic strategy with the appropriate choice of additive. Studies demonstrate that LiCl is essential for effective cross-coupling by accelerating the reduction of Ni(II) to Ni(0) and counteracting autoinhibition of reduction at Zn(0) by Zn(II) salts. The modified conditions tolerate a variety of functional groups on either coupling partner (42 examples), and examples include a three-step synthesis of flurbiprofen.
SDS of cas: 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Huang, LB; Ackerman, LKG; Kang, K; Parsons, AM; Weix, DJ or concate me.
Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
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