I found the field of Pharmacology & Pharmacy very interesting. Saw the article Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits published in 2019. Computed Properties of C7H4Cl2O2, Reprint Addresses Overkleeft, HS (corresponding author), Leiden Inst Chem, Gorlaeus Labs, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.; Overkleeft, HS (corresponding author), Netherlands Prote Ctr, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.; Groll, M (corresponding author), Tech Univ Munich, Lehrstuhl Biochem, Dept Chem, Ctr Integrated Prot Sci, D-85748 Garching, Germany.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid
Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the beta 1c, beta 1i, beta 5c, and beta 5i subunits exploit the differences in the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting beta 2c or beta 2i could not yet be rationally designed because of the high structural similarity of these two subunits. Here, we report the development, chemical synthesis, and biological screening of a compound library that led to the identification of the beta 2c- and beta 2i-selective-compounds LU-002c (4; IC50 beta 2c: 8 nM, IC50 beta 2i/beta 2c: 40-fold) and LU-002i (5; IC50 beta 2i: 220 nM, IC50 beta 2c/beta 2i: 45-fold), respectively. Co-crystal structures with beta 2 humanized yeast proteasomes visualize protein-ligand interactions crucial for subunit specificity. Altogether, organic syntheses, activity-based protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant differences of beta 2 substrate-binding channels and to complete the set of subunit-selective proteasome inhibitors.
Computed Properties of C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Xin, BT; Huber, EM; de Bruin, G; Heinemeyer, W; Maurits, E; Espinal, C; Du, YM; Janssens, M; Weyburne, ES; Kisselev, AF; Florea, BI; Driessen, C; van der Marel, GA; Groll, M; Overkleeft, HS or concate me.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics