Safety of 2,4-Dichlorobenzoic acid. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo published in 2020, Reprint Addresses Liu, XH; Shi, JB (corresponding author), Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China.. The CAS is 50-84-0. Through research, I have a further understanding and discovery of 2,4-Dichlorobenzoic acid.
Paeonol has been proved to have potential anti-inflammatory activity, but its clinical application is not extensive due to the poor anti-inflammatory activity (14.74% inhibitory activity at 20 mu M). In order to discover novel lead compound with high anti-inflammatory activity, series of paeonol derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. Structure-activity relationships (SARs) have been fully concluded, and finally (E)-N-(4-(2-acetyl-5-methoxyphenoxy)phenyl)-3-(3,4,5-trimet-hoxyphenyl) acrylamide (compound 1 la) was found to be the best active compound with low toxicity, which showed 96.32% inhibitory activity at 20 mu M and IC50 value of 6.96 mu M against LPS-induced over expression of nitric oxide (NO) in RAW 264.7 macrophages. Preliminary mechanism studies indicated that it could inhibit the expression of TLR4, resulting in inhibiting of NF-kappa B and MAPK pathways. Further studies have shown that compound 11a has obvious therapeutic effect against the adjuvant-induced rat arthritis model.
About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Hu, YS; Han, X; Yu, PJ; Jiao, MM; Liu, XH; Shi, JB or concate me.. Safety of 2,4-Dichlorobenzoic acid
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics