Recently I am researching about CROSS-COUPLINGS; KETONES; MONOARYLATION; AMINATION; LIGAND; METALATION; AMMONIA; HALIDES, Saw an article supported by the Universite de Lyon, IDEXLYON project [ANR-16IDEX-0005]; Agence Nationale de la RechercheFrench National Research Agency (ANR)European Commission [ANR-JCJC-2016-CHAUCACAO]; French Ministry of Higher Education and Research. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Abou Derhamine, S; Krachko, T; Monteiro, N; Pilet, G; Schranck, J; Tlili, A; Amgoune, A. The CAS is 95-49-8. Through research, I have a further understanding and discovery of 1-Chloro-2-methylbenzene. Quality Control of 1-Chloro-2-methylbenzene
The challenging nickel-catalyzed mono-alpha-arylation of acetone with aryl chlorides, pivalates, and carbamates has been achieved for the first time. A nickel/Josiphos-based catalytic system is shown to feature unique catalytic behavior, allowing the highly selective formation of the desired mono-alpha-arylated acetone. The developed methodology was applied to a variety of (hetero)aryl chlorides including biologically relevant derivatives. The methodology has been extended to the unprecedented coupling of acetone with phenol derivatives. Mechanistic studies allowed the isolation and characterization of key Ni(0)and Ni(II)catalytic intermediates. The Josiphos ligand is shown to play a key role in the stabilization of Ni(II)intermediates to allow a Ni-0/Ni(II)catalytic pathway. Mechanistic understanding was then leveraged to improve the protocol using an air-stable Ni(II)pre-catalyst.
Quality Control of 1-Chloro-2-methylbenzene. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Abou Derhamine, S; Krachko, T; Monteiro, N; Pilet, G; Schranck, J; Tlili, A; Amgoune, A or concate me.
Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics