Some common heterocyclic compound, 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, molecular formula is C6H3ClF2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H3ClF2O2S
To a 250 mL Erlenmeyer flask were added 3,5-difluorobenzenesulfonyl chloride (5.00 g, 23.5 mmol) and 50 mL of dichloromethane. A 26% solution of diethylamine (5.0 mL, 52.7 mmol) in water was added to the flask followed by DI water (40.0 mL). The solution was heated to 40 C for 24 h with vigorous stirring. The reaction mixture was then extracted twice with 25 mL portions of dichloromethane and the organic layer was subsequently washed with 50.0 mL of 5% HCl solution, DI water, 50.0 mL of 0.1 M NaOH solution, and finally water. The organic layer was then evaporated under reduced pressure to yield a yellow solid, which was then recrystallized from hexanes to afford 3.5 g (61%) of the title compound as a light yellow crystalline solid (m.p. 50-51 C). 1H NMR (CDCl3, delta): 7.4-7.5 (m, 2 H), 7.00 (tt, 1 H), 3.2-3.3 (q, 4 H), 1.2-1.3 (t, 6 H); 13C NMR (CDCl3, delta): 14 (s), 42 (s), 107 (t), 110 (dd), 143 (t), 162.9 (dd) all with respect to TMS at 0.0 ppm; 19F NMR (DMSO-d6, delta): -106.3. GC/MS: m/z: 249. Elemental analysis: Calc. Anal. for C10H13F2NSO2: C, 48.16; H, 5.26; Found: C, 48.07; H, 5.13.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 210532-25-5, its application will become more common.
Reference:
Article; Selhorst, Ryan; Fossum, Eric; Polymer; vol. 54; 2; (2013); p. 530 – 535;,
Chloride – Wikipedia,
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