Synthetic Route of 622-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 622-86-6 name is (2-Chloroethoxy)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The synthesis of Intermediates 8, 9 and 10 was carried out according to Hardcastle et al. (1995) and is shown in Scheme II.The mixture containing the tamoxifen precursor Intermediate 10 obtained after column chromatography was dried under high vacuum and minimum volume of absolute ethanol was added to dissolve it. It was heated to boiling and then transferred to the freezer at 0 0C. After 2 hrs it was brought out of the freezer and kept at room temperature. The sudden temperature difference makes the E- isomer to precipitate as fluffy white crystals that should be kept under constant supervision so as to filter the crystals off at the right moment before the Z-isomer also starts that has to be followed by 1H NMR of the precipitated crystals. EPO
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Chloroethoxy)benzene, and friends who are interested can also refer to it.
Reference:
Patent; YEDA RESEARCH AND DEVELOPMENT CO. LTD.; WO2006/80022; (2006); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics