Month: August 2021

Related Products of 2106-04-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2106-04-9, name is 3-Chloro-2-fluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(2S, 4S)-4- (4-CHLORO-QUINAZOLIN-7-YLOXY)-PYRROLIDINE-1, 2-DICARBOXYLIC acid 1-tert-butyl ester 2-methyl ester (L. OG, 2.45mmol) and 3-CHLORO-2-FLUOROANILINE (323F1, 2. 94mmol) were stirred in acetonitrile (25ml) and hydrogen chloride (736JELL of a 4M solution in dioxane, 2. 94mmol) was added. The mixture was heated at reflux for 2h, cooled and concentrated under reduced pressure. The residue was dissolved in methanol, absorbed onto and ISOLUTEE SCX column, washed with methanol and eluted with 7N ammonia in methanol. Appropriate fractions were combined and evaporated and the crudes purified by column chromatography on silica eluting with 7N ammonia in METHANOL/DICBLOROMETHANE (2/98) to give methyl (4S)-4- ( {4- [ (3-CHLORO-2-FLUOROPHENYL) AMINO] QUINAZOLIN-7-YL} OXY)-L-PROLINATE (811MG, 79%) as a white SOLID. 1H NMR spectrum : (DMSO d6) 2.09 (M, 1H) ; 2.54 (M, 1H) ; 2.80 (brs, 1H); 3.15 (M, 2H) ; 3.64 (s, 3H); 3.81 (dd, 1H) ; 5.11 (M, 1H); 7.16 (M, 2H); 7.28 (t, 1H) ; 7.51 (M, 2H); 8.35 (d, 1H) ; 8.44 (s, 1H); 7.80 (s, 1H); Mass Spectrum: (MH)+ 417.

The synthetic route of 3-Chloro-2-fluoroaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/30757; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H9ClO4S

-(isoindolin-2-ylsulfonyl)benzene-l,3-diol, 9 (PS2): In a 10 mL, three-necked, round-bottomed flask, 2,4-dimethoxybenzene-l-sulfonyl chloride (237 mg, 1 mmol, 1 equivalent) was dissolved in acetonitrile (3 mL) at room temperature. Triethylamine (0.3 mL) was added before isoindoline (238 mg, 2 mmol, 2 equivalent) was added. The mixture was stirred at the same temperature for 18 h and then diluted with ethyl acetate (50 mL). The mixture was washed sequentially with IN HC1 aqueous solution, saturated aqueous NaHC03, and brine. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to yield a solid, which was confirmed by NMR. NMR (500 MHz, CDC13) delta 7.95 (d, J=8.2 Hz, 2H), 7.29-7.25 (m, 2H), 7.22-7.20 (m, 2H), 6.55 (dd, J =8.2, 2.3 Hz, 1H), 6.44 (d, J =2.3 Hz, 1H), 4.76 (s, 4H), 3.86 (s, 3H), 3.76 (s, 3H); 13C NMR (125 MHz, CDC13) delta 164.9, 158.4, 136.9, 134.0, 127.6, 122.7, 118.8, 104.3, 99.5, 56.1, 55.9, 53.9. LRMS (ESI) calculated for [M+H]+ 320.1, found 320.0.

According to the analysis of related databases, 63624-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; CHUANG, David, T.; TSO, Shih-Chia; QI, Xiangbing; GUI, Wen-Jun; WU, Cheng-Yang; CHUANG, Jacinta, L.; TAMBAR, Uttam, K.; WYNN, R., Max; WO2015/89360; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 50638-47-6, name is 4-Bromo-2-chloro-1-methoxybenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50638-47-6, name: 4-Bromo-2-chloro-1-methoxybenzene

Example 20 5-(3-Chloro-4-methoxyphenyl)-5-(3-(3-fluoropropoxy)phenyl)-5H-pyrrolo[3,4-b]pyridin-7-amine tert-Butyllithium (1.7 M in pentane, 0.607 mL, 1.03 mmol) was added dropwise to THF (2 mL) at -100 C. under an argon atmosphere. Then a solution of 4-bromo-2-chloro-1-methoxybenzene (137 mg, 0.62 mmol) in THF (0.5 mL) was added dropwise followed by the addition of N-((2-cyanopyridin-3-yl)(3-(3-fluoropropoxy)phenyl)methylene)-2-methylpropane-2-sulfinamide (200 mg, 0.52 mmol) in THF (2 mL). The resulting reaction mixture was left on the thawing cooling bath for 30 min and then the cooling bath was removed and the mixture was stirred at rt for 1 h. Hydrogen chloride 1.25 M in methanol (2.478 mL, 3.10 mmol) was added and the resulting mixture was stirred at rt for 1 h. The mixture was concentrated and purified by preparative HPLC. The fractions containing the product were pooled and the MeCN was removed in vacuo. Saturated aqueous NaHCO3 was added to the residue and the mixture was extracted with DCM (3*10 mL). The combined organics were passed through a phase separator and concentrated to give 75 mg (34% yield) of the title compound: 1H NMR (DMSO-d6) delta ppm 8.55-8.69 (m, 1H) 8.19-8.32 (m, 1H) 7.42-7.52 (m, 1H) 7.27-7.32 (m, 1H) 7.22-7.27 (m, 1H) 7.16-7.22 (m, 1H) 7.01-7.07 (m, 1H) 6.86-6.91 (m, 1H) 6.67-6.86 (m, 4H) 4.61 (t, 1H) 4.52 (t, 1H) 3.96 (t, 2H) 3.80 (s, 3H) 2.05-2.10 (m, 1H) 2.00-2.05 (m, 1H); MS (ES+) m/z 426, 428 [M+1]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-chloro-1-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AstraZeneca AB; US2010/125087; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 95-81-8, These common heterocyclic compound, 95-81-8, name is 2-Chloro-5-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step C.; A solution of sodium nitrite (0.67 g, 9.94 mmol) and H2O (2.06 mL) was added dropwise at 0 C. to a solution of 2-chloro-5-methylbenzenamine (1.2 g, 8.29 mmol) in 12N HCl (12.8 mL) and TFA (2.5 mL). The reaction mixture was stirred at 0 C. for 1 h followed by the dropwise addition of a solution of tin(II)chloride (3.5 g, 18.2 mmol) in 12N HCl (4.9 mL) and H2O (0.7 ml) at 0 C. The reaction mixture stirred for 15 h at 20 C. and was filtered to give 1-(2-chloro-5-methylphenyl)hydrazine hydrochloride as a white solid (0.84 g, 4.3 mmol).

Statistics shows that 2-Chloro-5-methylaniline is playing an increasingly important role. we look forward to future research findings about 95-81-8.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/27178; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104-52-9, name is 3-Phenylpropyl Chloride, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

General procedure: Compounds A1-A20 were prepared following the previously reported method as described for A1 [1]. To a solution of 3-amino-5-mercapto-1,2,4-triazole (1.0 g, 8.61 mmol) in acetone was added sodium carbonate (1.37 g, 12.92 mmol) and alkyl halide (9.47 mmol). The mixture was then stirred at 60 oC for 3-6 h before cooling to room temperature. Upon completion of the reaction monitored by TLC, Na2CO3 were removed via filtration and the filtrate was evaporated under vacuum. The residue was purified by column chromatography, generating A1. 5-(((5-chlorobenzo[b]thiophen-3-yl)methyl)thio)-4H-1,2,4-triazol-3-amine, white solid, yield: 64 %.

The synthetic route of 104-52-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Shuai; Shen, Dandan; Zhao, Lijie; Yuan, Xiaohan; Cheng, Jialing; Yu, Bin; Zheng, Yichao; Liu, Hongmin; Chinese Chemical Letters; vol. 31; 2; (2020); p. 418 – 422;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6775-78-6, name is 6-Chloroimidazo[1,2-b]pyridazine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6775-78-6, Quality Control of 6-Chloroimidazo[1,2-b]pyridazine

Example 139 Production of 4-(imidazo[1,2-b]pyridazin-6-yloxy)aniline A mixture of 6-chloroimidazo[1,2-b]pyridazine (768 mg, 5.0 mmol), 4-aminophenol (818 mg, 7.5 mmol), potassium carbonate (2073 mg, 15.0 mmol) and N-methylpyrrolidone (5.0 mL) was stirred at 120 C. for 18 hr. The reaction mixture was diluted with 1N aqueous sodium hydroxide solution, and extracted with ethyl acetate. The organic layer was washed with 1N aqueous sodium hydroxide solution and saturated brine, and concentrated under reduced pressure. The residue was purified by NH silica gel column chromatography (hexane/ethyl acetate=70/30?0/100) and precipitated from diisopropyl ether to give the title compound (759 mg, 67%) as a gray powder. 1H-NMR (DMSO-d6, 300 MHz) delta 5.07 (2H, s), 6.60 (2H, d, J=8.9 Hz), 6.92 (2H, d, J=8.9 Hz), 7.00 (1H, d, J=9.8 Hz), 7.61 (1H, s), 8.01 (1H, s), 8.09 (1H, d, J=9.8 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Chloroimidazo[1,2-b]pyridazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/137595; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 694-80-4, name is 1-Bromo-2-chlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Bromo-2-chlorobenzene

REFERENCE EXAMPLE 10; 2-(2-Chlorophenyl)-6-methoxy-1 ,2,3,4-tetrahydroisoquinolin-1 -one; To a solution of 6-methoxy-1 ,2,3,4-tetrahydroisoquinolin-1-one (1.50 g, 8.5 mmol, obtained in reference example 9) in /V-methylpyrrolidone (4 ml_) under argon, 1- EPO bromo-2-chlorobenzene (2.34 g, 12.3 mmol), copper (I) iodide (0.33 g, 1.7 mmol) and potassium carbonate (2.33 g, 16.9 mmol) were added and the mixture was heated at 200 0C overnight. It was allowed to cool and CHCI3 and 1 N NaOH were added. The phases were separated and the aqueous phase was reextracted 2 times with CHCI3. The combined organic phases were dried over Na2SO4 and the solvent was evaporated. The crude product thus obtained was purified by chromatography on silica gel using hexane-EtOAc mixtures of increasing polarity as eluent, to afford 2.01 g of the desired compound (yield: 77%). LC-MS (method 1): tR = 8.05 min; m/z = 288.1/290.1 [M+Hf.

The synthetic route of 1-Bromo-2-chlorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; J. URIACH Y COMPANIA S.A.; WO2007/337; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 104-11-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 104-11-0, name is 1-(4-Chlorophenyl)-N-methylmethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 22 (0.60 g, 3.85 mmol) and K2CO3 (0.71 g, 5.14 mmol) in anhydrous acetonitrile (150 mL) under N2 at 0 C, was added crude 21(o) (0.58 g, 2.57 mmol) and the reaction heated and allowed to progress under reflux for 6 h. Acetonitrile was then removed under reduced pressure and the reaction mixture worked up with ethyl acetate (100 mL) and saturated aqueous Na2CO3 (3 × 50 mL), dried (MgSO4) and concentrated in vacuo. The crude product was purified by column chromatography using mixtures of ethyl acetate:hexane (5:95) to (20:80) as eluent to give12(o)a as a yellow oil (0.45 g, 58%); 1H NMR (CDCl3, 400 MHz) delta 7.39-7.26 (9H, m, ArH), 4.55 (2H, s, H-1), 3.58 (2H, s, H-8), 3.50 (2H, s, H-10), 2.13 (3H, s, H-9); 13C NMR (CDCl3, 75 MHz) delta 137.4 (Arqu), 137.1 (Arqu), 134.7 (Arqu), 132.7 (Arqu), 130.7 (ArC-H), 130.2 (C-12/16), 129.6 (ArC-H), 128.3 (C-13/15), 128.1 (ArC-H), 127.7 (ArC-H), 61.5 (C-10), 59.9 (C-8), 52.0 (C-1), 41.9 (C-9). HRMS (ES): Found 301.1211 (M + H)+: C16H18ClN4 (M + H)+ requires 301.1215.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Chlorophenyl)-N-methylmethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zishiri, Vincent K.; Hunter, Roger; Smith, Peter J.; Taylor, Dale; Summers, Robert; Kirk, Kiaran; Martin, Rowena E.; Egan, Timothy J.; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1729 – 1742;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C6H3BrCl2

Under a nitrogen atmosphere, tert-butyllithium (1.3 Msolution in Pentane, 17.8 mL, 23.2 mmol) was added dropwise to a solution of 3,5-dichlorobenzene (5.0 g, 22.1mmol) in tetrahydrofuran (50 mL) for 30 min and the reaction was continued for 2 hours. Trifluoroacetic anhydride is then added(2.56 g, 12.2 mmol) was added dropwise to the mixed solution and stirring was continued for 2 hours while maintaining at -78 ° C. Remove the cold, gradually rose toAfter room temperature, keep the reaction at room temperature for 2.5 hours. Saturated ammonium chloride solution (50 mL) was added to terminate the reaction. The mixture was extracted with etherThe organic phase was combined and washed with saturated brine (20 mL’2). The organic phase was separated and washed with anhydrous magnesium sulfateDrying, filtration, removal of the solvent, and distillation under reduced pressure gave a colorless transparent liquid 1 (2.58 g) in a yield of 48percent.

The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jingmen Pharmaceutical Industry Technology Institute; Wang Yong; Li Liwei; Hu Jianmei; Gu Dongyun; Huang Daoyou; (12 pag.)CN107353189; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 39226-96-5, name is (2-Chloro-3-(trifluoromethyl)phenyl)methanamine, molecular formula is C8H7ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H7ClF3N

Example 23 N-{[2-Chloro-3-(trifluoromethyl)phenyl]methyl}-3-methyl-2-oxo-1-(2- pyridinyl)-4-imidazolidinecarboxamide (E23) (in a form obtainable or prepared from (4S)-2-oxo-3-{[(phenylmethyl)oxy]carbonyl}-4-imidazolidinecarboxylic acid); A mixture of 3-methyl-2-oxo-1-(2-pyridinyl)-4-imidazolidinecarboxylic acid TFA salt (117 mg, 0.35 mmol), 1-hydroxybenzotriazole hydrate (80 mg, 0.525 mmol), 1-ethyl- 3-(3-dimethylaminopropyl)carbodiimide hydrochloride (101 mg, 0.525 mmol) and N- ethyl morpholine (0.224 ml, 1.75 mmol) in dichloromethane (8 ml) was stirred at room temperature for 10 minutes. A solution of {[2-chloro-3- (trifluoromethyl)phenyl]methyl}amine (73.4 mg, 0.35 mmol) in dichloromethane (2 ml) was added and the reaction stirred at room temperature for 18 hours. The mixture was partitioned between dichloromethane and saturated sodium hydrogen carbonate solution. The organic phase was separated, washed with water and brine, dried and evaporated. The residue was purified by silica gel chromatography eluting with 0- 10% methanol in dichloromethane to give N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-3-methyl-2-oxo-1-(2-pyridinyl)-4- imidazolidinecarboxamide (90 mg, 62%). LC/MS [M+H]+ = 413, retention time = 2.55 minutes.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 39226-96-5, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/119825; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics