The important role of 2,4-Dimethoxybenzene-1-sulfonyl chloride

According to the analysis of related databases, 63624-28-2, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H9ClO4S

-(isoindolin-2-ylsulfonyl)benzene-l,3-diol, 9 (PS2): In a 10 mL, three-necked, round-bottomed flask, 2,4-dimethoxybenzene-l-sulfonyl chloride (237 mg, 1 mmol, 1 equivalent) was dissolved in acetonitrile (3 mL) at room temperature. Triethylamine (0.3 mL) was added before isoindoline (238 mg, 2 mmol, 2 equivalent) was added. The mixture was stirred at the same temperature for 18 h and then diluted with ethyl acetate (50 mL). The mixture was washed sequentially with IN HC1 aqueous solution, saturated aqueous NaHC03, and brine. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to yield a solid, which was confirmed by NMR. NMR (500 MHz, CDC13) delta 7.95 (d, J=8.2 Hz, 2H), 7.29-7.25 (m, 2H), 7.22-7.20 (m, 2H), 6.55 (dd, J =8.2, 2.3 Hz, 1H), 6.44 (d, J =2.3 Hz, 1H), 4.76 (s, 4H), 3.86 (s, 3H), 3.76 (s, 3H); 13C NMR (125 MHz, CDC13) delta 164.9, 158.4, 136.9, 134.0, 127.6, 122.7, 118.8, 104.3, 99.5, 56.1, 55.9, 53.9. LRMS (ESI) calculated for [M+H]+ 320.1, found 320.0.

According to the analysis of related databases, 63624-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; CHUANG, David, T.; TSO, Shih-Chia; QI, Xiangbing; GUI, Wen-Jun; WU, Cheng-Yang; CHUANG, Jacinta, L.; TAMBAR, Uttam, K.; WYNN, R., Max; WO2015/89360; (2015); A1;,
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