Adding a certain compound to certain chemical reactions, such as: 694-80-4, name is 1-Bromo-2-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 694-80-4, Quality Control of 1-Bromo-2-chlorobenzene
General procedure: A 10 mL Schlenk tube equipped with a magnetic stirring bar was charged with 2-arylimidazo[1,2-a]pyridine 1 (0.2 mmol, 1.0 equiv), o-dihaloarene2 (0.3 mmol, 1.5 equiv), and K2CO3 (82.9 mg, 0.6 mmol, 3.0 equiv). To this mixture were added Pd(OAc)2 (0.02 mmol, 4.5 mg)and Xphos (0.04 mmol, 19.1 mg), followed by DMF (2.0 mL) via a syringe at r.t. The tube was sealed and kept in a preheated oil bath at 160 C for 24 h. The mixture was cooled to r.t., quenched with H2O (5mL), and diluted with CH2Cl2 (10 mL). The layers were separated and the aqueous layer was extracted with CH2Cl2 (3 × 5 mL). The combined organic extracts were dried (Na2SO4), filtered, and concentrated in vacuo. The crude product was then purified by flash chromatography on silica gel (H), eluting with 5-20% EtOAc-petroleum ether.
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Reference:
Article; Wang, Hanyang; Chen, Chunxia; Huang, Zhangjie; Yao, Liping; Li, Bin; Peng, Jinsong; Synthesis; vol. 47; 16; (2015); p. 2457 – 2466;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics