Electric Literature of 694-80-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 694-80-4, name is 1-Bromo-2-chlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A mixture of the aryl halide(1 mmol), phenylboronic acid (0.1463 g, 1.2 mmol) or Ph4BNa (0.0855 g, 0.25 mmol),K2CO3 (0.2764 g, 2 mmol), ortho-palladated complex (0.0006 g, 0.1 mmol%) was addedto ethanol (2 ml) in round-bottom flask equipped with condenser and placed into theMilestone microwave oven. Initially the microwave irradiation was set at 600 W and thetemperature was raised to the desired temperature of 60C and the reaction mixture washeld at this temperature until the reaction was completed. The direct control of reactionmixture temperature was carried out using the IR sensors and software that enables on-linetemperature-pressure control by regulation of microwave power output. The mixture wasstirred continuously during the reaction and monitored by both TLC and GC. After thereaction was completed, the mixture was cooled to room temperature and was diluted withether (2 × 10 ml) and water (10 ml). The organic phase was dried overMgSO4, filtered andconcentrated under reduced pressure using a rotary evaporator. The residue was purified bysilica gel column chromatography (n-hexane:EtOAc, 9:1). The products were characterizedby comparing their mp., IR, 1H, 13C NMR spectra with those reported in the literature.Also Suzuki cross coupling reaction was carried out successfully in larger scale(30 mmol of aryl halide) using this ortho-palladated complex (0.018 g).
The synthetic route of 1-Bromo-2-chlorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hajipour, Abdol Reza; Rafiee, Fatemeh; Organic Preparations and Procedures International; vol. 45; 6; (2013); p. 465 – 472;,
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