Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39065-95-7, name is 4-(Chlorodifluoromethoxy)aniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H6ClF2NO
The compound 4-(chlorodifluoromethoxy)aniline (2.86 g, 14.6 mmol) was dissolved in 20 mL of DMF, and 5-bromo-6-chloronicotinic acid (3.45 g, 14.6 mmol), HATU (6.66 g, 17.52 mmol) and DIPEA (3.77 g, 29.2 mmol), stirred at room temperature for 2 hours. The reaction solution was poured into 100mL water and extracted three times with 20mL of ethyl acetate, the combined ethyl acetate and washed with saturated brine. Dry over anhydrous sodium sulfate and concentrate by filtration. Column chromatography (petroleum ether / ethyl acetate, 3/1) gave white solid powder 3.35 g. The yield was 60.3%.
The synthetic route of 39065-95-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Zhao Jiuyang; (35 pag.)CN109651359; (2019); A;,
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