1940-29-0, name is 4-Bromo-3,5-dichloroaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C6H4BrCl2N
*5*.(4-Bromo-3,5-dichloro-phenyl)-l-(4-methoxy-benzyl)-N*3*,N*3*-dimethyl-lH- [l,2,4]triazole-3,5-diamine In a 25 mL round bottle, 5-bromo-l-(4-methoxybenzyl)-N,N-dimethyl-lH-l,2,4-triazol-3-amine (lg, 3.21 mmol, Eq: 1.00) was combined with DMF (18.4 ml) to give a colorless solution. 4- bromo-3,5-dichloroaniline (774 mg, 3.21 mmol, Eq: 1.00) and sodium 2-methylpropan-2-olate (618 mg, 6.43 mmol, Eq: 2.00) were added. The reaction was degassed by nitrogen for 5 min. The resulting solution was heated to 85 C overnight under nitrogen. The reaction mixture was cooled and diluted with 20 mL H20, added EtOAc (30×2 mL) to extract the product, dried the organic layer over anhydrous Na2S04, concentrate the solution, purify the compound by column (Hexanes/EtOAc = 70/30) to afford the compound 40mg (3%). MH+ 472.0
The synthetic route of 1940-29-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DING, Qingjie; JIANG, Nan; WEIKERT, Robert James; WO2014/135472; (2014); A1;,
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