Synthetic Route of 694-80-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 694-80-4, name is 1-Bromo-2-chlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2-nitroaniline 6.9g 49.95mmol in toluene (100mL), bromochlorobenzene 9.56g (49.95mmol), tris(dibenzylideneacetone) dipalladium(0)(tris(dibenzylideneacetone)dipalladium(0)), 1.44g (2.5mmol) , BINAP 2.33g (3.75mmol), was put cesium carbonate(caesium carbonate) 32.6g (99.91mmol) was refluxed at 120 C under a nitrogen atmosphere. After the reaction was completed after the filters using a Celite (celite) and Florisil (florisil) and washed with MC. By column chromatography and purified using an MC and Hex to give the title compound 1-5 10.7g (86%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-chlorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hee SungMaterial Co., Ltd; Go, Hay Jin; Kim, Sin Tae; Kim, Gi Yong; Lee, Do Hyung; Uhm, Sung Jin; Lee, Ju Dong; (37 pag.)KR2015/30056; (2015); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics