Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, A new synthetic method of this compound is introduced below., name: Methyl 2,2,2-trichloroacetimidate
Example 129: f/?)-//,//-Diethyl-5-(3-(pyrrolidine-1-carbonyl)piperidin-1-yl)-3/-/- imidazo[4,5-blpyridine-2-carboxamide Into a vial containing (‘ ?^-(1-(5,6-diaminopyridin-2-yl)piperidin-3-yl)(pyrrolidin-1- yl)methanone dihydrochloride (125 mg, 0.3 mmol) was added formic acid (73.5 muIota_, 1.7 mmol) followed by 2,2,-trifluoroethanol (1.7 mL) and methyl 2,2,2-trichloroacetimidate (47.0 muIota_, 0.4 mmol). The vial was sealed and stirred at room temperature for 13 min. The reaction mixture was heated to 60C and stirred for 3 h at that temperature. An aliquot of 0.3 mL was transferred into another vial containing diethylamine (89.1 mu, 0.9 mmol). The resulting mixture was heated to 60C and stirred for 16 h. The reaction mixture was concentrated under reduced pressure and the resulting residue was partitioned between water and ethyl acetate. The aqueous was further extracted with ethyl acetate. The combined organics were concentrated under reduced pressure. The residue was purified via HPLC to afford the title compound. MS (ESI+) (M+H) 399.1 ; HPLC retention time 1 .9864 min (Method A).
The synthetic route of 2533-69-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; AHN, Kay; BOEHM, Markus; CABRAL, Shawn; CARPINO, Philip A.; FUTATSUGI, Kentaro; HEPWORTH, David; KUNG, Daniel W.; ORR, Suvi; WANG, Jian; WO2013/150416; (2013); A1;,
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