Synthetic Route of 2533-69-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2533-69-9 name is Methyl 2,2,2-trichloroacetimidate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(a) First step: preparation of 2-trichloromethyl-1H-benzimidazole: Methyl trichloroacetimidate (12.8 ml, 0.103 mol) was added dropwise over 30 minutes to 1,2-phenylenediamine (10.8 g, 0.1 mol) dissolved in 250 ml of acetic acid at 150 C. and with stirring. The mixture was maintained under stirring for 5 hours at room temperature. The reaction mixture and poured into water. The precipitate formed was filtered off, washed with water and dried. 23.1 g (yield=98%) of an off-white powder of 2-trichloromethyl- 1H-benzimidazole were obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2,2,2-trichloroacetimidate, and friends who are interested can also refer to it.
Reference:
Patent; Societe L’Oreal S.A.; US6221343; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics