Adding a certain compound to certain chemical reactions, such as: 102-49-8, name is 3,4-Dichlorobenzylamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102-49-8, Application In Synthesis of 3,4-Dichlorobenzylamine
A mixture of 3,4-dichlorobenzylamine (440 mg, 2.5 mmol) and acrylimide (185 mg, 2.6 mmol) was treated with silicon tetrachloride (6 mul, 0.05 mmol) under solvent-free conditions at 0°C. The mixture was heated to 60°C and stirred for 4 hr. The reaction was allowed to cool to rt and ethyl acetate (20 mL) and water (20 mL) were added. The layers were separated and the aqueous layer was further extracted with ethyl acetate (2 x 20 mL) and the combined organic layers were dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash column chromatography eluting with a gradient of dichloromethane: methanol (95:5 ? 85:15) to yield the product as a white solid (378 mg, 61percent).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4-Dichlorobenzylamine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Brear, Paul; North, Andrew; Iegre, Jessica; Hadje Georgiou, Kathy; Lubin, Alexandra; Carro, Laura; Green, William; Sore, Hannah F.; Hyvoenen, Marko; Spring, David R.; Bioorganic and Medicinal Chemistry; vol. 26; 11; (2018); p. 3016 – 3020;,
Chloride – Wikipedia,
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