Related Products of 918538-05-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 918538-05-3 name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a 25mL reaction vial, Pd(PPh3)2Cl2 (19mg, 0.027mmol) and 2N Na2CO3 solution (0.27mL, 0.54mmol) were added to a solution of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester (55mg, 0.27mmol) and 12 (50mg, 0.27mmol) in dioxane (5mL). The mixture was stirred at 70C for 16h under N2 atmosphere. The reaction mixture was cooled to room temperature and filtrated. The filtrate was diluted with H2O (100mL) and then extracted with EtOAc, and the organic layer was dried over anhydrous Na2SO4, After filtration, the filtrate was evaporated and purified by chromatography (petroleum ether/EtOAc, 5:1) to give the product 20 as a yellow solid (55mg, 88%). MS (ESI) m/z: [M+H]+=234. 1H NMR (400M, DMSO-d6) delta 8.87 (s, 1H, ArH), 8.38 (s, 1H, ArH), 8.14 (s, 1H, ArH), 7.53 (d, 1H, J=4.8Hz, ArH), 7.10 (dd, 1H, J1=2.4Hz, J2=4.8Hz, ArH), 3.98 (s, 3H, ArCH3) ppm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, and friends who are interested can also refer to it.
Reference:
Article; Xin, Minhang; Zhang, Liandi; Tang, Feng; Tu, Chongxing; Wen, Jun; Zhao, Xinge; Liu, Zhaoyu; Cheng, Lingfei; Shen, Han; Bioorganic and Medicinal Chemistry; vol. 22; 4; (2014); p. 1429 – 1440;,
Chloride – Wikipedia,
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