Related Products of 102-49-8,Some common heterocyclic compound, 102-49-8, name is 3,4-Dichlorobenzylamine, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of the compound 2 (0.15 g, 0.39 mmol) in CH2Cl2 (10 mL) were added 3,4-dichlorobenzylamine (0.22 g, 0.47 mmol), HATU (0.178 g, 0.468 mmol), DIPEA (79 muL, 0.975 mmol). The mixture was stirred at room temperature for 45 min. Subsequently, the reaction mixture was transferred to a separators funnel and washed with 1 N HCl (10 mL), saturated NaHCO3, water, and brine. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to obtain compound 3a (0.177 g, 97percent yield) as a yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Dichlorobenzylamine, its application will become more common.
Reference:
Article; Wang, Boyu; Wang, Kuanglei; Meng, Peipei; Hu, Yaping; Yang, Fei; Liu, Kemin; Lei, Zaiqiang; Chen, Binfeng; Tian, Yongshou; Bioorganic and Medicinal Chemistry Letters; vol. 28; 21; (2018); p. 3477 – 3482;,
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