Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 61881-19-4
General procedure: A mixture of acetimidoyl chloride (1 mmol), sodium azide (1 mmol), and acetonitrile (3 mL) was irradiated in a microwave oven at 300 W for 8-10 min, after completion of the reaction, as indicated by TLC, the reaction mixture was filtered. After removing the solvent under reduced pressure, if necessary, the crude products were purified by washing with n-hexane to give the target product 3a-3j (90-95%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 61881-19-4, its application will become more common.
Reference:
Article; Rahmani, Fariba; Darehkordi, Ali; Notash, Behrouz; Journal of Fluorine Chemistry; vol. 166; (2014); p. 84 – 87;,
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