Application of 1996-29-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of 1-bromo-4-chloro-2-fluorobenzene (5 g, 23.87mmol) in tetrahydrofuran (40 mL) was cooled to -78 C was added LDA, 2M inTHF/heptane/ethylbenzene (14.92 mL, 29.8 mmol) dropwise and the reaction mixture was stirred at this temperature for 30 mm. The solution was allowed to warm to -20 C and stirred for 30 mm. The reaction was cooled to -78 C and trimethyl borate (3.47 mL, 31.0 mmol) dissolved in THF (5 mL) was addeddropwise and the reaction mixture was warmed to -20 C and stirred for 1 h. The reaction mixture was cooled to -78 C and peracetic acid (16 mL, 84 mmol) was added dropwise and the mixture allowed to warm to rt and stirred for 12 h. The reaction mixture was cooled to 0 C and quenched with 5% aqueous ammonium chloride and extracted with ethyl acetate (2X50 mL). The combined organiclayers were washed with brine (50 mL). The organic layer was dried over sodium sulphate and concentrated under reduced pressure to yield 3-bromo-6-chloro-2- fluorophenol (4.99 g, 18.25 mmol, 76% yield) as yellow oil. LCMS (ESI) m/e 225.1 [(M+H), calcd for C6H4BrC1FO 224.9]; LC/MS retention time (method G): tR = 0.87 mm.
The synthetic route of 1-Bromo-4-chloro-2-fluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; VRUDHULA, Vivekananda M.; PAN, Senliang; RAJAMANI, Ramkumar; MACOR, John E.; BRONSON, Joanne J.; DZIERBA, Carolyn Diane; NARA, Susheel Jethanand; KARATHOLUVHU, Maheswaran Sivasamban; WO2015/38112; (2015); A1;,
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