Electric Literature of 1996-29-8,Some common heterocyclic compound, 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-bromo-4-chloro-2-fluorobenzene (61 g, 291 mmoles), 2,6-dimethoxyphenylboronic acid (50.4 g, 277 mmoles), K2 CO3 (60.4 g, 437 mmoles) and Pd (PPh3) 4 (10.1 g, 8.7 mmoles)Put in a round bottom flask,And then dissolved in 500 ml of THF and 200 ml of distilled water,And the solution was refluxed and stirred at 60 C for 12 hours.When the reaction is complete,The aqueous layer was removed and passed through column chromatography (hexane: DCM 20%)Process the remainder to obtain 38 grams of intermediate 1(51%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-chloro-2-fluorobenzene, its application will become more common.
Reference:
Patent; SAMSUNG SDI CO., LTD.; Kang, Dong Min; Kim, Jun Seok; Lui, Jinhyun; Lee, Byoungkwan; Lee, Sangshin; Won, Jonswoo; Lee, Namheon; Jung, Sung Hyun; Jung, Ho Kuk; (107 pag.)TW2019/43698; (2019); A;,
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