Introduction of a new synthetic route about 1-Bromo-4-chloro-2-fluorobenzene

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1996-29-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Bromo-4-chloro-2-fluorobenzene

Carbazole (20.0 g, 119.6 mmol) and KF-alumina (30.0 g, 179.4 mmol) under a stream of nitrogenAnd 18-crown-6 (6.3 g) was placed in 120 mL of dimethyl sulfoxide (DMSO; Dimethylsulfoxide) solvent and stirred with heating.1-Bromo-4-chloro-2-fluorobenzene (25.1 g, 119.6 mmol) was added under reflux.After stirring for 8 hours, it was cooled to normal temperature, and the resulting solid was filtered to obtain a compound of the formula 2-2-A (35.1 g, yield 83%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1996-29-8.

Reference:
Patent; Co., Ltd. LG Chemical; Han Meilian; Li Dongxun; Xu Jingwu; Zhang Fenzai; Xu Dongxu; Zheng Minyou; (51 pag.)CN108218802; (2018); A;,
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