In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4584-46-7 as follows. Application In Synthesis of 2-Chloro-N,N-dimethylethanamine hydrochloride
Caesium carbonate (3.0 Eq), sodium iodide (0.14 Eq) and 2-chloro-N,N- dimethylethylamine hydrochloride (1.5 Eq) are added to a suspension of p-bromo-phenol (1.0 Eq) in butanone (50 mL). The suspension is kept under reflux for four hours, after which the solid is filtered through a Hirsch funnel and washed with acetone, and the solvent is evaporated at low pressure. The crude product (yellow oil) is purified by silica-gel chromatography (eluent: dichloromethane-methanol; 95:5) to obtain the desired product (2-p-bromophenoxyethyl-N,N-dimethylamine) as a colourless oil (yield 70%).
According to the analysis of related databases, 4584-46-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITA’ DEGLI STUDI DI MILANO; FUMAGALLI, Laura; PICOZZI, Claudia; REGAZZONI, Luca; CARINI, Marina; ALDINI, Giancarlo; VISTOLI, Giulio; (26 pag.)WO2019/53626; (2019); A1;,
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