Month: June 2021

Synthetic Route of 2106-02-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2106-02-7, name is 2-Chloro-4-fluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

a 2-Chloro-4-fluorophenylisothiocyanate Into a solution of 2-chloro-4-fluoroaniline (500 mg, 3.44 mmol) in a mixture of chloroform and water (10 mL/10 mL) at room temperature, thiophosgene (0.53 mL, 6.88 mmol) and sodium bicarbonate (1.09 g, 10.32 mmol) were added. The mixture was stirred at room temperature for 16 hours. The mixture was partitioned between chloroform and water. The combined organic layer was then concentrated to give the desired product (586 mg, 91%). 1H NMR (CDCl3) delta 6.98 (m, 1H), 7.20 (m, 2H).

The synthetic route of 2-Chloro-4-fluoroaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Palovich, Michael R.; Widdowson, Katherine L.; Nie, Hong; US2003/216375; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69957-83-1, name is N-Ethyl-4-chlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H12ClN

[4-(2-{[2-(Methoxycarbonyl)phenyl]thio} ethyl) phenoxy] acetic acid (0.200 [G,] 0.577 mmol) was dissolved in DMF (10 ml), [N-(4-CHLOROBENZYL)-N-ETHYLAMINE] (0.108 g, 0.635 mmol) was added and the mixture was cooled to 0 C. N-[(1H-1, 2, 3-benzotriazol-1- yloxy) (dimethylamino) [METHYLENE]-N-METHYLMETHANAMINIUM] tetrafluoroborate (0.204 g, 0.635 mmol) and N-ethyl-N,N-diisopropylamine (0.157 g, 1.212 mmol) were added. The solution was stirred overnight at room temperature. Water (100 [ML)] was added and the water phase was extracted with diethyl ether (3 X 20ml). The organic phase was washed with [NA2CO3] (3 X 20 ml, [AQ)] and HCl (0.5 M, 2 X, 10 [ML).] The organic layer was dried (MgSO4) and the solvent was removed by evaporation. The residue was purified by flash chromatography (started with isocratic heptane/EtOAc 30/70 and then the EtOAc concentration was increased to 100%, (silica gel 60 0.004-0. 063 [MM).] The product containing fractions were pooled and the solvent was removed by evaporation to give 0. [085 G OF METHYL 2-{ [2-(4-{2-[(4-CHLOROBENZYL)] (ethyl) [AMINO]-2-] oxoethoxy} phenyl) ethyl] thio} benzoate (yield 29.6%). [1HNMR] (rotamers, 300 MHz, CDC13) : 8 1.09-1. 21 [(M,] 3H), 2.91-2. 99 [(M,] 2H), 3.11-3. 18 [(M,] 2H), 3.32-3. 43 [(M,] 2H), 3.92 (s, [3H),] 4.57-4. 75 [(M,] 4H), 6.78, 6.92 (d, d, 2H), 7.12- 7.46 [(M,] 9H), 7.96 (d, [1H).]

According to the analysis of related databases, 69957-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/294; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 14862-52-3, The chemical industry reduces the impact on the environment during synthesis 14862-52-3, name is 3,5-Dibromochlorobenzene, I believe this compound will play a more active role in future production and life.

3,5-dibromochlorobenzene (2.7 g, 10 mmol)9-phenylcarbazole-3-boronic acid (6.0 g, 21 mmol)Sodium carbonate (10.2 g, 96 mmol),Pd2 (dba) 3 (0.4 g, 0.4 mmol), toluene,Ethanol, water 50ml in turn added to the reaction bottle,The reaction was refluxed under nitrogen for 10 hours, cooled to room temperature,The aqueous layer was extracted with ethyl acetate,The organic layers were combined, washed with saturated brine and water, respectively,The organic layer was dried over magnesium sulfate, filtered,Filtrate spin dry, over silicone column,4.4 g of product was obtained, HPLC purity 99.2%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromochlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CECEP Wanrun Co., Ltd.; Yu Kaichao; Zhang Zhaochao; Wang Lichun; (35 pag.)CN107056806; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-tert-Butyl-4-chlorobenzene

20 parts of water,40 parts of acetone,And 20 parts of potassium carbonate were mixed,Three parts of raw material A are added. After stirring for 1 hour,10 parts of raw material B was charged, the temperature was raised to 50 ° C. while stirring,Stir for an additional 1 hour. after that,Concentrate using a rotary evaporator,And dried to obtain a dispersant.N – (4 – aminophenyl) acetamide was used as the raw material A of the dispersant preparation example,Using 1-tert-butyl-4-chlorobenzene as the raw material B,Dispersant 1 was obtained.

According to the analysis of related databases, 3972-56-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dispersed materials Institute; Umemura, Kazuyuki; Ito, Shiho; Suzuki, Junji; Nishida, Atsushi; (15 pag.)JP2016/108519; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1005-56-7 as follows. Recommanded Product: 1005-56-7

Methyl-5-Jf-acetamido-3 , 5-dideoxy-3- f luoro- 8 , 9- 0-isopropylidene-4- O- (phenoxy) thiocarbonyl-D- eryt+/-ro-/?- L-manno-2 -nonulopyranosonate 19 :19To a solution of 18 (1.949 g, 5.1 mmol) in 70 mL dry DCM and 35 mL pyridine, phenylchlorothionoformate (761 muL, 5.6 mmol) was added at -400C and stirred for 30 minutes at this temperature. The mixture was then brought to room temperature and stirred for further 4 hours. MeOH (5 mL) was then added and after 10 minutes the -crude mixture was concentrated in .vacuo. and purified by column chromatography (EtOAc/MeOH 100:1) to give 19. Colorless solid (2.065 g, 76%) . 1H-NMR (400 MHz, CDCl3) delta 1.35 (s, 3H, Me2C), 1.40 (s, 3H, Me2C), 2.35 (s, 3H, NHAc), 3.49 (m, IH, H-5), 3.86 (s, 3H, OMe), 4.07 (dd, J = 21.5, 10.5 Hz, IH, H-9) , 4.37 (m, IH, H-9′), 4.45 (d, J = 4.9 Hz, IH, H-8), 4.58 (q, J = 2.7 Hz, IH, H-6), 5.16 (dd, J = 25.4, 1.7 Hz, IH, H-3), 5.69 (d, J = 3.6 Hz, IH, H-7), 6.11 (ddd, J = 8.7, 23.1 Hz, IH, H-4) , 6.25 (d, J = 8.2 Hz, IH, NHAc), 7.06 – 7.45 (m, 5H, OPh)

According to the analysis of related databases, 1005-56-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE UNIVERSITY OF BATH; WATTS, Andrew, Graham; WO2010/29302; (2010); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 94-97-3, name is 5-Chloro-1H-benzo[d][1,2,3]triazole, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 94-97-3, SDS of cas: 94-97-3

General procedure: A mixture of azole (0.2 mmol), ketone (0.3 mmol, 1.5equiv.), NaHCO3 (33.6 mg, 2.0 equiv.), I2 (101.6 mg, 2.0 equiv.), and 1,2-dichloroethane (2 mL) was stirred at 80 C for 24 h. After cooling to room temperature, the reaction mixture was quenched with a saturated solution of Na2S2O3 (5 mL) and extracted with ethyl acetate (3×5 mL). The combined organic phases were washed with brine (10 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated. The residue was purified by flash column chromatograph, using a mixture of petroleum ether and ethyl acetate (5:1-2:1) as eluent to afford the corresponding products. The identity and purity of the products was confirmed by 1H and 13C NMR spectroscopic analysis.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Chen, Wenlin; Yan, Rulong; Tang, Dong; Guo, Shuaibo; Meng, Xu; Chen, Baohua; Tetrahedron; vol. 68; 38; (2012); p. 7956 – 7959;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 13918-92-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13918-92-8, name is 2,4-Difluorobenzene-1-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4.00 g (21.4 mmol) C-3, 4.3 mL (32 mmol) 2,4-difluorobenzenesulfonyl chloride, 5.2 mL (64 mmol) pyridine and 50 mL DCM is stirred at RT for 5 h. After completion of the reaction, the solvent is removed under reduced pressure, the crude product is taken up in 50 mL water and extracted twice with 100 mL DCM. The combined organic layers are dried over MgSO4 and the solvent is removed under reduced pressure. The crude product can be used without further purification. Yield: 7.88 g (91%).

The chemical industry reduces the impact on the environment during synthesis 2,4-Difluorobenzene-1-sulfonyl chloride. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; The designation of the inventor has not yet been filed; EP2546249; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 93765-83-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 93765-83-4, name is 1-Bromo-5-chloro-2-fluoro-4-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation 12To a solution of 1-bromo-5-chloro-2-fluoro-4-methylbenzene (Comm, 10 g, 44.7 mmol) in methanol (200 ml_) was added 1 ,1′-binaphthalene-2,2′-diylbis(diphenylphosphine) – dichloropalladium (1:1) (358 mg, 0.447 mmol) and N,N-diethylethanamine (8.11 ml_, 58.2 mmol). The resulting mixture was placed in a bomb and pressurized with carbon monoxide to 80 psi and heated at 80C for 18 hours. The reaction mixture was then concentrated in vacuo to yield a semi-solid, which was dissolved in EtOAc (300 ml_) and washed with water (200 mL). The organic layer was separated, dried over magnesium sulphate, filtered and concentrated in vacuo to yield an orange oil, which solidified on standing (9.87 g). The solid was purified by silica gel chromatography eluting with 0 to 20% EtOAc in heptane to afford the title compound as a crystalline white solid (8.47 g, 93%).1H NMR (400 MHz, CDCI3): delta 2.40 (s, 3H), 3.92 (s, 3H), 7.03 (d, 1 H), 7.91 (d, 1 H) LCMS Rt = 1 .64 minutes Molecular ion not observed

The synthetic route of 1-Bromo-5-chloro-2-fluoro-4-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; BROWN, Alan, Daniel; RAWSON, David, James; STORER, Robert, Ian; SWAIN, Nigel, Alan; WO2012/7868; (2012); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 29671-92-9, name is Carbamimidic chloride hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29671-92-9, COA of Formula: CH4Cl2N2

(1) Add methyl 3-amino-5-bromopyrimidinecarboxylate (6.2 g, 27 mmol) to a 250 mL sealed tube.Chloroformamidine hydrochloride (3.4 g, 30 mmol) and dimethyl sulfone (50.8 g, 20 mmol) were heated to 140oC and stirred for 6 hours. After cooling to room temperature, 50 mL of water was added to the reaction solution, followed by ultrasonication for 30 minutes. The residue was filtered. Water, acetone washing, vacuum drying to obtain a tan solid 1 (yield = 65%),

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Carbamimidic chloride hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tsinghua University; Liao Xuebin; He Lei; Wang Zhisong; Gao Yan; (59 pag.)CN108069963; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 60811-18-9,Some common heterocyclic compound, 60811-18-9, name is 4-Bromo-1-chloro-2-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a. 4-chloro-3-fluorobenzoylpropionic acid To a solution of succinic anhydride (6.0 g) in tetrahydrofuran (60 ml) was added dropwise the Grignard prepared from 1.5 g (0.062 mole) of magnesium turnings and 10.5 g (0.05 mole) of 1-bromo-4-chloro-3-fluorobenzene using the procedure of part a. When the addition was completed, the resulting suspension was stirred for 2 hours at 45 C. after which water (100 ml) was added slowly and the resulting mixture was acidified with concentrated hydrochloric acid to pH=1. The ether layer was separated and extracted with 5% aqueous sodium hydroxide (3*100 ml). The combined aqueous solutions were washed with ether (1*100 ml). The combined basic aqueous layers were acidified with concentrated hydrochloric acid to pH 1 and extracted with ethyl acetate (3*150 ml). The combined organic extracts were washed with water (1*150 ml) and brine (1*150 ml), dried over anhydrous magnesium sulfate and evaporated in vacuo to give 7.1 g (62%) of the product as a yellow orange solid. The resulting acid was converted to the desired product using the procedure of Example 11d-e. Compound 83 was prepared following essentially the same procedure.

The synthetic route of 60811-18-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rohm and Haas Company; US5552409; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics