10061-02-6, name is trans-1,3-Dichloropropene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C3H4Cl2
(1), the (E)- 1, 3 – dichloropropene (354g, 3.20 muM) added to the tetrahydrofuran (1.5L) solution, light added under mixing sodium iodide (595g, 3.2 muM), stirring at the room temperature 2h, preparation of (E)-1 – chloro -3 – iodo propylene reaction liquid for use. The (S)-4 – phenyl -2 oxazolidone (720g, 2.91 mol) is added to the tetrahydrofuran (2L) solution, lowering the temperature to -10 C, dropwise 1N II (trimethyl silicon-based) amino lithium (486.8g, 2 . 91 muM) tetrahydrofuran solution (3L), to maintain the temperature of the reaction solution is lower than the -10 C, after the completion of the dropping -10 C reaction 2h, then adding the above-mentioned preparation of (E)-1 – chloro -3 – iodo acrylic solution. Then slow heating to 10 C, overnight reaction. TLC monitoring raw material the reaction is complete. The reaction liquid is poured into the saturated NH4Cl solution (5L) quenching, steaming and remove a portion of the solvent, and then the extraction of ethyl acetate concentrate (2L × 3), combined with the several phase, anhydrous sodium sulfate drying, steaming and to job 1 kg brown oily matter, directly used for the next step reaction.
The synthetic route of 10061-02-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; Liu Wei; Ma Shimin; (29 pag.)CN104058990; (2017); B;,
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