Related Products of 104-52-9,Some common heterocyclic compound, 104-52-9, name is 3-Phenylpropyl Chloride, molecular formula is C9H11Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Aluminum chloride (160 g, 1.2 mol, 2 q) was added to a 500 ml three-necked flask to keep the reaction solution at a temperature of not higher than -15 C. Pre-mixed 3-chlorophenyl propane (93 g, 0.6 mol, lq) and n-octanoyl chloride (116 g, 0.72 mol, 1.2 eq). After completion of the dropwise addition, the reaction was complete at -5 C until the reaction was complete [reaction takes about 8 to 14 hours, HPLC detection: 3-chlorophenylpropane The mixture was slowly poured into 1200 ml of 5% hydrochloric acid and extracted with ethyl acetate (200 ml x 3 times). The organic layers were combined and the organic layer was washed with saturated brine, dried over anhydrous sodium sulfate (50 g) was dried and filtered, and the filtrate was concentrated at about no more than 40 C to give a yellow oil to octanoylchloropropylbenzene (152 g, HPLC purity 95.86% yield 90%).
The synthetic route of 104-52-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHENGDU HONGDA PHARMACEUTICAL CO., LTD.; KE, XIAO; CHANG, HEXI; YE, YONG; (13 pag.)CN103804123; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics